Luteinizing Hormone, Porcine, Native

Cat. No.	Size	Price
New RP178310200	200 IU	$245
New RP1783102000	2000 IU	$997,5
New RP178310800	800 IU	$525

Technical Data

Type

Native protein

Description

Porcine Luteinizing Hormone is a glycosylated, polypeptide chain which stimulates maturation of follicle, induces ovulation, accelerates formation of corpus luteum and secretion of pregnanolone. Porcine Luteinizing Hormone delays ovulation and ovarian cyst.

Source

Porcine

Formulation

Sterile filtered and lyophilized with no additives.

Reconstitution

It is recommended to reconstitute the lyophilized Porcine LH in sterile 18M-cm H2O at 100IU/4ml, which can then be further diluted to other aqueous solutions.

Applications

Reproduction

Storage/Expiration

Lyophilized Porcine LH is stable at room temperature for 3 weeks. Upon reconstitution LH should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze-thaw cycles.

Summary

Research topic

Reproduction

Summary

Luteinizing hormone is a part of a neurological pathway comprised of the hypothalamus, the pituitary gland, and gonads. In this pathway, LH release is stimulated by gonadotropin-releasing hormone (GnRH) and inhibited by estrogen in females and testosterone in males. LH has various functions, which differ between male and female. In both sexes, LH contributes to the maturation of primordial germ cells. In male, LH causes the Leydig cells of the testes to produce testosterone. In female, LH triggers the creation of steroid hormones from the ovaries. Additionally, LH in female, plays roles in both ovulation and implantation of an egg in the uterus.

Summary References (22)

References to LH

Bardin CW, Paulsen CA. "The Testes" in Textbook of Endocrinology, (ed.) R.H. Williams M.D., W.B. Saunders Co. 1981;
Boyar R, Finkelstein J, Roffwarg H, Kapen S, Weitzman E, Hellman L. Synchronization of augmented luteinizing hormone secretion with sleep during puberty. N Engl J Med. 1972 Sep 21;287 (12):582-6
Cohen KL. Metabolic, endocrine, and drug-induced interference with pituitary function tests: a review. Metabolism. 1977 Oct;26 (10):1165-77
Cumming DC, Reid RL, Quigley ME, Rebar RW, Yen SS. Evidence for decreased endogenous dopamine and opioid inhibitory influences on LH secretion in polycystic ovary syndrome. Clin Endocrinol (Oxf). 1984 Jun;20 (6):643-8
Cumming DC, Vickovic MM, Wall SR, Fluker MR. Defects in pulsatile LH release in normally menstruating runners. J Clin Endocrinol Metab. 1985 Apr;60 (4):810-2
Engvall E. Enzyme immunoassay ELISA and EMIT. Methods Enzymol. 1980;70 (A):419-39
Ferin M, Van Vugt D, Wardlaw S. The hypothalamic control of the menstrual cycle and the role of endogenous opioid peptides. Recent Prog Horm Res. 1984;40:441-85
Harris GW, Naftolin F. The hypothalamus and control of ovulation. Br Med Bull. 1970 Jan;26 (1):3-9
Hoff JD, Quigley ME, Yen SS. Hormonal dynamics at midcycle: a reevaluation. J Clin Endocrinol Metab. 1983 Oct;57 (4):792-6
Hoff JD, Quigley ME, Yen SS. Hormonal dynamics at midcycle: a reevaluation. J Clin Endocrinol Metab. 1983 Oct;57 (4):792-6
Hosseinian AH, Kim MH. Predetermination of ovulation timing by luteinizing hormone assay. Fertil Steril. 1976 Apr;27 (4):369-74
Jeffcoate SL. The control of testicular function in the adult. Clin Endocrinol Metab. 1975 Nov;4 (3):521-43
Knobil E. The neuroendocrine control of the menstrual cycle. Recent Prog Horm Res. 1980;36:53-88
Krieger DT. Placenta as a source of 'brain' and 'pituitary' hormones. Biol Reprod. 1982 Feb;26 (1):55-71
Marshall JC. Clinics in endocrinology and metabolism. Investigative procedures. Clin Endocrinol Metab. 1975 Nov;4 (3):545-67
Pierce JG, Parsons TF. Glycoprotein hormones: structure and function. Annu Rev Biochem. 1981;50:465-95
Rebar R, Judd HL, Yen SS, Rakoff J, Vandenberg G, Naftolin F. Characterization of the inappropriate gonadotropin secretion in polycystic ovary syndrome. J Clin Invest. 1976 May;57 (5):1320-9
Ross GT, VandeWeile RL, Frantz AG. Chapter 7 in "The Ovaries and the Breasts" in "Textbook of Endocrinology" (R. H. Williams, Ed.), W.B. Saunders Co. 1981;
Shome B, Parlow AF. Human follicle stimulating hormone (hFSH): first proposal for the amino acid sequence of the alpha-subunit (hFSHa) and first demonstration of its identity with the alpha-subunit of human luteinizing hormone (hLHa). J Clin Endocrinol Metab. 1974 Jul;39 (1):199-202
Simpson ER, MacDonald PC. Endocrine physiology of the placenta. Annu Rev Physiol. 1981;43:163-88
Uotila M, Ruoslahti E, Engvall E. Two-site sandwich enzyme immunoassay with monoclonal antibodies to human alpha-fetoprotein. J Immunol Methods. 1981;42 (1):11-5
Whitley RJ, Keutmann HT, Ryan RJ. Studies on the isolation and chemical-physical properties of porcine follicle-stimulating hormone. Endocrinology. 1978 Jun;102 (6):1874-86

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