E-Selectin (Endothelial Leukocyte Adhesion Molecule-1, ELAM-1, Leukocyte endothelial cell adhesion molecule 2, LECAM2, CD62E antigen)

E-selectin belongs to the selectin family of adhesion molecules. Together with LECAM-1 (L-selectin) and GMP-140 (P-selectin), E-selectin mediates the initial interactions of leukocytes and platelets with endothelial cells. E-selectin is expressed on cytokine-activated endothelial cells, and contributes to the adhesion of resting leukocytes to the endothelium. Determination of sE-selectin could provide more detailed insights into the pathological modifications during various diseases.