Granzyme A (Cytotoxic T-lymphocyte proteinase 1, Hanukkah factor, CTL tryptase, Fragmentin 1, T-lymphocyte associated serine esterase 3)

Granzymes are exogenous serine proteinases (enzymes) that are released from cytoplasmic granules of cytotoxic lymphocytes and NK cells. Percentages of the Granzyme A and B positive CTLs can be determined by flow cytometry and immunocytochemical methods for many disorders (viral infections, lymphomas, carcinomas, rheumatoid arthritis and transplantation).