Granzyme B (T-cell serine protease 1, Cytotoxic T-lymphocyte proteinase 2, Granzyme 2, Cathepsin G like 1, Fragmentin 2)

Granzymes are exogenous serine proteinases (enzymes) that are released from cytoplasmic granules of cytotoxic lymphocytes and NK cells. Percentages of the Granzyme A and B positive CTLs can be determined by flow cytometry and immunocytochemical methods for many disorders (viral infections, lymphomas, carcinomas, rheumatoid arthritis and transplantation).