ICAM-1 (Intercellular adhesion molecule 1, Major group rhinovirus receptor, CD54 antigen, Surface antigen of activated B cells)

ICAM-1 (55 kDa) is a member of the immunoglobulin supergene family that functions as a ligand for the Lymphocyte Function-Associated Antigen-1. It is a single-chain glycoprotein that can be expressed on non-hematopoietic cells of many lineages. The role of ICAM-1 as a disease marker has been demonstrated for a number of different indications and pathological situations. ICAM-1 upregulation in allergic airway inflammation is responsible for the recruitment of activated leukocytes and the pathogenesis of allergic rhinitis. In lymphoproliferative disorders, ICAM-1 is related to the degree of malignancy.