ICAM-3 (Intercellular adhesion molecule 3, CD50 antigen)

ICAM-3 is a member of the immunoglobulin supergene family and functions as a ligand for the Lymphocyte Function-Associated Antigen-1. ICAM-3 is a heavily glycosylated protein of 124 kDa with a polypeptide core of 57 kDa. ICAM-3 is absent in endothelia. It is expressed on resting lymphocytes, monocytes and neutrophils, representing the major LFA-1 ligand on these cells. ICAM-3 is a very interesting molecule involved in the initial immune response, thus suggesting an important role as a disease marker for a number of different indications and pathological situations.