Interleukin-18 (IL-18, Interferon-gamma-inducing factor, Interleukin-1 gamma, IL-1 gamma, Iboctadekin, IGIF, IL1F4, IL-1g, MGC12320, IFN gamma inducing factor)

Interleukin-18 belongs to IL-1 family is a novel cytokine that plays an important role in the T-cell-helper type 1 (Th1) response, primarily by its ability to induce IFN gamma production in T cells and natural killer (NK) cells. IL-18 expression is detected in many different cells including macrophages, keratinocytes, and osteoblasts.