MLC-I (Myosin Light Chain-I)

Human ventricular myosin light chain (MLC-I, Essential Myosin Light Chain Isoform) is a 21 kDa cardiac contractile protein, which is one of component of myosin structure. The protein MLC-I is present in the contractile apparatus and not in cytosol. In severe congestive heart failure (CHF), myofibrils may degenerate and, subsequently, the myofibrillar components may be released into the circulation. The increased blood levels of MLC-I could indicate morphological changes in CHF, myocardial infarction, structural abnormalities in viable myocytes also observed in non-ischaemic CHF, myocardial necrosis.