MMP-13 (Collagenase 3, Matrix metalloproteinase-13, CLG3)

MMP-13 is a member of the matrix metralloproteinases family with broad substrate specificity and a potential role in tumor metastasis and invasion. MMP-13 was originally identified in breast carcinomas. Further studies revealed that this enzyme is produced by a variety of malignant tumors. It is a major player in the disease condition of rheumatoid arthritis and osteoarthritis.