P-Selectin (Granule membrane protein 140, PADGEM, Leukocyte-endothelial cell adhesion molecule 3, CD62P antigen, Granulocyte membrane protein, PSGL-1)

P-selectin belongs to the selectin family of adhesion molecules. P-selectin acts as a receptor that supports binding of leukocytes to activated platelets and endothelium. P-selectin-mediated adhesive interactions operate in conjunction with cell-cell interactions directed by related molecules and are likely to be important in both hemostatic and inflammatory processes. The physiological role of P-selectin may be the mediation of initial leukocyte adhesion to activated endothelium during acute inflammation. Soluble P-selectin is a potentially important molecule that may provide more detailed insight into pathological situations.