14-3-3 β Human,
Mouse Monoclonal Antibody, Clone: 60C10

Introduction to the Molecule

14–3–3, a family of acidic and soluble proteins, highly conserved in amino acid sequences from yeast to mammals, is xpressed in all eukaryotic cells. Seven isoforms(β, γ, ε, η, ζ, σ and τ/θ) encoded by seven distinct genes are identified in mammals and forms homo- and heterodimeric cup-shaped structures. As 14–3–3 is interacted with more than 100 binding partners, it regulates key proteins involved in various biological processes such as signal trans-duction, cell cycle, transcriptional control, cell proliferation, apoptosis, and ion channel physiology. Most 14–3–3 requires phosphorylation of serine or threonine residues in the target sequence. This protein is abundantly expressed in the brain and has been detected in the cerebrospinal fluid of patients with different neurological disorders.

Source of Antigen

E.coli

Host

Mouse

Isotype

IgG2b, kappa

Preparation

PBS containing 50% glycerol

Species Reactivity

Human (+), Mouse (+), Rat (+)

Storage/Stability

Store for 1 year at –20°C from date of shipment

Applications

Western blotting

By molecule:

• 14-3-3