Alpha-1-antitrypsin precursor Human,
Mouse Monoclonal Antibody, Clone: 48D2

Research topic

Immune Response, Infection and Inflammation

Introduction to the Molecule

Alpha-1-antitrypsin (α-1-AT) is a 52 kDa glycoprotein, which is produced by the liver, intestinal macrophages, monocytes and mucous membrane cells of the gut. It belongs to the group of acute phase proteins and is one of the most important proteinase inhibitor. α-1-AT inhibits, beside others, the proteinases trypsin and the elastase of neutrophiles. A lack of α-1-AT leads to an enhanced proteolysis. Only a very small amount of α-1-AT is cleaved or resorbed in the gut. Therefore the measurement of α-1-AT in stool reflects the permeability of the gut during inflammatory processes.

Source of Antigen

Human plasma

Host

Mouse

Isotype

IgG1, k

Preparation

Hepes with 0.15 M NaCl, 0.01% BSA, 0.05% Sodium azide and 50% glycerol

Species Reactivity

Human (+), Mouse (NT), Rat (NT)

Storage/Stability

Store for 1 year at –20℃ from date of shipment.

Applications

Western blotting

By research topic:

• Immune Response, Infection and Inflammation

By molecule:

• Alpha-1-Antitrypsin