C1 inhibitor Human,
Mouse Monoclonal Antibody, Clone: 4G12

Introduction to the Molecule

C1 inhibitor (C1-INH) is a serine protease inhibitor that inactivates several different proteases in the complement, contact, coagulation, and fibrinolytic systems. Though C1-INH has 478 residues (53kDa), the circulating protein is approximately 104 kDa by post-translational modification. Deficiency of C1-INH results in hereditary angioedema. In addition, C1– INH may prove useful in a variety of other diseases including septic shock, reperfusion injury, hyperacute transplant rejection, traumatic and hemorrhagic shock.

Source of Antigen

Human plasma

Host

Mouse

Isotype

IgG1, kappa

Preparation

PBS containing 50% glycerol

Species Reactivity

Human (+), Mouse (NT), Rat (NT)

Storage/Stability

Store for 1 year at –20°C from date of shipment

Applications

Immunoprecipitation, Western blotting

By molecule:

• C1 inhibitor