Complement factor H Human,
Mouse Monoclonal Antibody, Clone: 34F12

Introduction to the Molecule

The complement system is a crucial component of the innate immunity against microbial infection. Complement factor H, a 155 kDaplasma glycoprotein, is an essential regulatory protein that plays a critical role in the homeostasis of the complement system in plasma and in the protection of bystander host cells and tissues from damage by complement activation. Factor H binds to C3b, accelerates the decay of the alternative pathway C3-convertase and acts as a cofactor for the factor Imediated proteolyticinac­tivation of C3b. In addition, factor H has multiple physiological activities acts as an extracellularmatrix component, binds to cellular receptors of the integrintype, and interacts with a wide selection of ligands, such as the C-reactive protein, thrombospondin, bone sialoprotein, osteopontin, and heparin. Complement factor H has revealed an association with two different renal diseases, glomerulonephri­tisand atypical hemolytic uremicsyndrome (aHUS).

Source of Antigen

Human plasma

Host

Mouse

Isotype

IgG1, kappa

Preparation

PBS containing 50% glycerol

Species Reactivity

Human (+), Mouse (NT), Rat (NT)

Storage/Stability

Store for 1 year at –20°C from date of shipment

Applications

ELISA, Western blotting

By molecule:

• Complement factor H