Diazepam Binding Inhibitor Human,
Mouse Monoclonal Antibody, Clone: 27C9

Introduction to the Molecule

Diazepam Binding Inhibitor(DBI) is a highly conserved 10 kDa polypeptide which is expressed in various species range from yeast to mammals. As an inverse agonist for benzodiazepine receptors, DBI downregulates inhibitory effects of GABA. It also has potential to induce anxiety. Found in central and peripheral tissues, DBI also participates in metabolism of steroids, which has been known to partially modify GABAA receptor function in the CNS. In peripheral tissues, DBI plays regulatory roles in steroidogenesis. DBI levels have been reported to be decreased in the cerebrospinal fluid obtained from patients with Alzheimer disease.

Source of Antigen

E.coli

Host

Mouse

Isotype

IgG2b, kappa

Preparation

PBS containing 50% glycerol

Species Reactivity

Human (+), Mouse (-), Rat (-)

Storage/Stability

Store for 1 year at –20°C from date of shipment

Applications

ELISA, Immunohistochemistry, Immunoprecipitation, Western blotting

By molecule:

• Diazepam Binding Inhibitor