Gamma Enolase Human,
Mouse Monoclonal Antibody, Clone: 85F11

Introduction to the Molecule

Enolase (2-phosphoglycerate hydrolyase or phosphopyruvate hydrates) is a glycolytic enzyme that catalyzes the dehydration and conversion of 2-phosphoglycerate to phosphoenolpy­ruvate. It comprises three distinct subunits, α, β and γ. The γγ and αγ dimeric forms of enolase, referred to as neuron-specific enolase(NSE), are localized mainly in neurons and neuroectodermal tissue. NSE has a high stability in biological fluids and can easily diffuse to the extracellular medium and cerebrospinal fluid(CSF) when neuronal membranes are injured. NSE is used clinically as a sensitive and useful marker of neuronal damage in several neurological disorders including stroke, hypoxic brain damage, status epilepticus, Creutzfeldt- Jakob disease, and herpetic encephalitis.

Source of Antigen

E.coli

Host

Mouse

Isotype

IgG2a, kappa

Preparation

PBS containing 50% glycerol

Species Reactivity

Human (+), Mouse (+), Rat (-)

Storage/Stability

Store for 1 year at –20°C from date of shipment

Applications

Western blotting

By molecule:

• gamma Enolase