Haptoglobin Human,
Mouse Monoclonal Antibody, Clone: 26E11

Introduction to the Molecule

Haptoglobin (abbreviated as Hp) is a protein in the blood plasma that binds free hemoglobin released from erythrocytes with high affinity and thereby inhibits its oxidative activity. Hp in its simplest form consists of two α- and two β-chains, connected by disulfide bridges. The chains originate from a common precursor protein which is proteolytically cleaved during protein synthesis. Hp exists in two allelic forms in the human population, so called Hp1 and Hp2; the latter one having arisen due to the partial duplication of Hp1 gene. Three phenotypes of Hp are found in humans: Hp1–1, Hp2–1, and Hp2–2. Hp phenotypes are associated with pathogenesis of a number of human disorders, such as diabetes, cardiovascular disease, etc. Hp plays a role in the host defence responses to infection and inflammation, acting as a natural antagonist for receptor-ligand activation of the immune system, also.

Source of Antigen

Human plasma

Host

Mouse

Isotype

IgG1, kappa

Preparation

PBS containing 50% glycerol

Species Reactivity

Human (+), Mouse (NT), Rat (NT)

Storage/Stability

Store for 1 year at –20℃ from date of shipment

Applications

ELISA, Western blotting

By molecule:

• Haptoglobin