IκB kinase β (IKKβ) Human,
Mouse Monoclonal Antibody, Clone: 42D1

Introduction to the Molecule

IκB kinase β (IKKβ) is a component of a multiprotein kinase complex that regulates the activity of the transcription factor NF- κB. Activation of the IKK complex via upstream stimuli leads to phosphorylation and degradation of NF-κB bound IκB (Inhibitor of κB). Subsequently, free NF-κB dimers enter the nucleus and regulate the transcription of a variety of target genes involved in cell proliferation and differentiation, apoptosis, and inflammation, etc. The IKK complex consists of 2 highly homologous kinase subunits, IKKα and IKKβ, and a nonenzymatic regulatory component, IKKγ/NEMO. The relative contributions of IKKα and IKKβ to the signaling complex vary according to the requirements of the cell. IKKβ plays a predominant role in immune responses, while IKKα alone appears to be sufficient for at least some developmental systems. Recently, IKK/NF-κB signaling pathway was studied as therapeutic targets in cancer.

Source of Antigen

E.coli

Host

Mouse

Isotype

IgG2b, kappa

Preparation

Hepes with 0.15 M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Species Reactivity

Human (+), Mouse (+), Rat (+)

Storage/Stability

Store for 1 year at –20℃ from date of shipment

Applications

ELISA, Immunoprecipitation, Western blotting

By molecule:

• IKKβ