Inter-alpha-trypsin inhibitor heavy chain H4 Human,
Mouse Monoclonal Antibody, Clone: 45A12

Introduction to the Molecule

The inter-α-trypsin inhibitor (ITI, IαI) family, a typical and classical example for protein-glycosaminogly­canprotein (PGP) complexes, occurs constitutively in plasma at relatively high concentrations and is a result of alternate combinations of three kinds of heavy chains with a common light chain, the bikunin proteoglycan. Bikunin has two proteinase inhibitor domains and belongs to the Kunitz-type protease inhibitor family; it displays an inhibitory activity against trypsin, leukocyte elastase and plasmin. The heavy chains do not have any protease inhibitory properties but have the capacity
o interact in vitro and in vivo with hyaluronic acid and this binding promotes the stability of the extra-cellular matrix. The ITI protein family is suspected of playing a key role in the extra-cellular matrix biology.

Source of Antigen

Human plasma

Host

Mouse

Isotype

IgG1, kappa

Preparation

Hepes with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Species Reactivity

Human (+), Mouse (NT), Rat (NT)

Storage/Stability

Store for 1 year at –20℃ from date of shipment.

Applications

ELISA, Western blotting

By molecule:

• inter-α-trypsin inhibitor