Methionine Sulfoxide Reductase A Human,
Mouse Monoclonal Antibody, Clone: 1C8

Introduction to the Molecule

Methionine sulfoxide reductase (MsrA) reduces methionine sulfoxide (MetO) residues in proteins and free MetO to Methionine (Met). The catalytic activity of MsrA is dependent of bound metal and cofactors but it requires reducing equivalents from either DTT or a thioredoxin-regenerating system. MsrA plays an essential role in protecting cells against oxidative damage. The substrates of MsrA include calmodulin, HIV protease and α1-proteinase-inhibitor. Recent studies indicate that there is a connection between MsrA and Alzheimer’s disease in mammals.

Source of Antigen

E.coli

Host

Mouse

Isotype

IgG1, kappa

Preparation

PBS containing 50% glycerol

Species Reactivity

Human (+), Mouse (+), Rat (-)

Storage/Stability

Store for 1 year at –20°C from date of shipment

Applications

Immunoprecipitation

By molecule:

• Methionine Sulfoxide Reductase A