Nck1 Human,
Rabbit Polyclonal Antibody

Research topic

Bone and cartilage metabolism, Cardiovascular disease, Cytokines and chemokines and related molecules

Introduction to the Molecule

Pleiotrophin (Osteoblast-Specific Factor-1, OSF-1) contains 136 amino acid residues. The sequence is very rich in cationic amino acids (24% of the residues); lysine cluster sequences are found in the N-terminal and C-terminal ends of the structure.

The OSF-1 gene was shown by Northern blotting analysis to be expressed in mouse calvarial osteoblast-enriched cells and in mouse brain tissues, but not in thymus, spleen, kidney, liver, lung, testis or heart.

Pliotrophin has the ability to promote adhesion, migration, expansion, and differentiation of human osteoprogenitor cells. In addition to certain types of cancer, the embryonic growth and differentiation factor pleiotrophin is found also in adults in inflammatory diseases. In osteoarthritis, pleiotrophin is especially expressed in early stages, and its concentrations in the synovial fluid could serve as a marker for the progress of the disease. Pleitrophin might be involved in cartilage repair in osteoarthritis, in particular, in earlier stages.

Source of Antigen

Synthetic peptide

Host

Rabbit

Isotype

IgG

Preparation

Hepes with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Species Reactivity

Human (+), Mouse (+), Rat (-)

Storage/Stability

Store for 1 year at –20℃ from date of shipment.

Applications

Western blotting

By research topic:

• Bone and cartilage metabolism
• Cardiovascular disease
• Cytokines and chemokines and related molecules

By molecule:

• Osteoblast Specific Factor 1
• Osteoblast Specific Factor 2
• NCK1