Phospho-Stat3(Y705) MAPK Human,
Mouse Monoclonal Antibody, Clone: 6A1

Introduction to the Molecule

Signal transducer and activator of transcription (STAT), named after their dual role, are latent cytoplasmic transcription factors that mediate various biological responses. The activation of STAT proteins is largely mediated by phosphorylation of C-terminal transactivation domain through Janus kinases (JAKs) and mitogen-activated protein kinases (MAPKs), which allows the activated STATs to dimerize and to translocate into the nucleus. By modulating target gene expression, STAT proteins play an important role in mediating a broad range of biological processes such as cell proliferation, survival, apoptosis, and differentiation. Seven mammalian members of the STAT family are known (STAT1, 2, 3, 4, 5a, 5b, and 6) and they all share common features and structure. STAT3 is activated by growth factors and oncogenic kinases where it mediates transcriptional activation of genes encoding apoptosis inhibitors, cell-cycle regulators and inducers of angiogenesis.

Source of Antigen

Synthetic peptide

Host

Rabbit

Isotype

IgG

Preparation

Hepes with 0.15M NaCl, 0.01% BSA, 0.05% Sodium azide and 50% glycerol

Species Reactivity

Human (+), Mouse (NT), Rat (NT)

Storage/Stability

Store for 1 year at –20℃ from date of shipment.

Applications

Western blotting

By molecule:

• STAT3