S100B Bovine,
Mouse Monoclonal Antibody, Clone: SB6

Research topic

Neural tissue damage markers

Introduction to the Molecule

S-100B protein is a member of highly homologous acidic calcium and zinc binding proteins family (S100 family) that possess two EF-hand motifs. S100B is a  homodimer with the molecular weight 21 kDa. S100B is abundant in the nervous system where it is predominantly expressed in astrocytes, oligodendrocytes and Schwann cells. S100B is released from brain tissue into cerebrospinal fluid (CSF) and blood following brain damage of different origin, i.e., brain infarction, intracerebral or subarachnoidal hemorrhage, neurotrauma and large intracerebral tumors. It is documented a relationship between degree of cell damage and S100B levels in CSF. Also patients with progressive melanoma disease show elevated serum concentrations of S100B.

Source of Antigen

Bovine

Host

Mouse

Isotype

IgG2a, kappa

Preparation

PBS containing 50% glycerol

Species Reactivity

Human (+), Bovine (+), Mouse (+), Rat (+)

Storage/Stability

Store for 1 year at –20°C from date of shipment

Applications

Immunohistochemistry, Immunoprecipitation, Western blotting

By research topic:

• Neural tissue damage markers

By molecule:

• S100B