Selenoprotein-P Human,
Mouse Monoclonal Antibody, Clone: 37A1

Introduction to the Molecule

Selenoprotein-P(SelP) is the major selenoprotein in human blood plasma and a transport protein which is carrying selenium to various extrahepatic tissues. Though its expression is detected in most tissues, highest amounts are produced by the liver, which secretes highly glycosylated SelP into plasma. Purification of human SelP yields two distinct isoforms with 61 and 55 kDa, differing in selenium content. SelP also has been shown to chelate heavy metals such as cadmium and mercury, and there are several evidences about its serum antioxidant capacity and protection against oxidative stress. Selenium deficiency predispose to several pathological condition such as cancer, coronary heart disease and liver necrosis although the biological function of SelP in various pathologic conditions has not been established.

Source of Antigen

Human plasma

Host

Mouse

Isotype

IgG1, kappa

Preparation

PBS containing 50% glycerol

Species Reactivity

Human (+), Mouse (NT), Rat (NT)

Storage/Stability

Store for 1 year at –20℃ from date of shipment

Applications

ELISA, Immunohistochemistry, Western blotting

By molecule:

• Selenoprotein-P