Serum amyloid P component Human,
Mouse Monoclonal Antibody, Clone: 6E6

Introduction to the Molecule

Serum amyloid P component (SAP) is a normal plasma protein and a universal non-fibrillar constituent of amyloid deposits. SAP is a member of the pentraxin protein family which includes Creactive protein. Human SAP is secreted and catabolized only by hepatocytes, and consists of five identical non-covalently associated subunits, each with a molecular mass of 25 kDa, which are non-covalently associated in a pentameric disc-like ring. SAP is a calcium-dependent ligand binding protein, which binds to DNA and chromatin, and to all known types of amyloid fibrils accounting for its specific accumulation in amyloid deposits. Serum amyloid P component scintigraphy is a non-invasive and quantitative method for imaging amyloid deposits, which produces diagnostic images in most patients with systemic amyloidosis, and can be used repeatedly to monitor the course of the disease.

Source of Antigen

Human plasma

Host

Mouse

Isotype

IgG1, kappa

Preparation

PBS containing 50% glycerol

Species Reactivity

Human (+), Mouse (NT), Rat (NT)

Storage/Stability

Store for 1 year at –20℃ from date of shipment

Applications

Immunoprecipitation, Western blotting

By molecule:

• Serum amyloid P component