Ubiquitin+1 Human,
Mouse Monoclonal Antibody, Clone: 40B3

Introduction to the Molecule

Ubiquitin+1 (Ub+1) is a novel mutant form of ubiquitin that can be produced through a process known as molecular frameshift. Ub+1 can be polyubiquitinated to produce aberrant polyubiquitin chains that inhibit the 26S proteasome. Especially ub+1 is accumulated in aggregates containing amyloid-beta and phosphorylated-tau. Elevated expression of Ub+1 mRNA and protein has been observed in the brains of patients with Alzheimer's di­sease. Also ub +1 acts as an aggravating factor in polyglutamine-induced neurodegeneration.

Source of Antigen

Synthetic peptide (KLH coupled) corresponding to C-terminal residues of human Ubiquitin +1.

Host

Mouse

Isotype

IgG1, kappa

Preparation

PBS containing 50% glycerol

Species Reactivity

Human (+), Mouse (NT), Rat (NT)

Storage/Stability

Store for 1 year at –20°C from date of shipment

Applications

Immunoprecipitation, Western blotting

By molecule:

• Ubiquitin+1