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Products\Immunoassays\2 Screen Islet Cell Autoantibody Human ELISA:
2 Screen Islet Cell Autoantibody Human ELISA
| Other names: | 2 Screen , GAD, IA-2 | ||
|---|---|---|---|
| Cat. No.: |
 R2GI/96R |
Regulatory status: RUO | |
| Size: | 96 wells (1 kit) | | | |
| Files: | Datasheet PDF (RUO) | ||
| Legend: | new product discount |
 temporarily out of stock order in advance |
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Research topic
Autoimmunity, Diabetology
Storage/Shipping
Sera to be analysed should be assayed soon after separation or stored, preferably in aliquots, at or below –20°C.
Summary
Autoantibodies to pancreatic beta cell antigens are important serological markers of type 1 diabetes mellitus. The antigens recognised by these autoantibodies include insulin, glutamic acid decarboxylase (GAD65 kDa isoform) and an islet cell antigen named IA-2 or ICA-512. 2 Screen ELISA allows simultaneous measurement of GAD and IA- 2 autoantibodies in the same sample.
Assay format
Sandwich ELISA, Biotin-labelled antibody
Applications
Serum
Calibration range
4 – 450 U/ml
Limit of detection
0.17 U/ml
Intra-assay
CV = 3.9%
Inter-assay
CV = 5.5%
References to summary
- Chen S, Willis J, Maclean C, Ananieva-Jordanova R, Amoroso MA, Brooking H, Powell M, Collins A, Bennett S, Mitchell S, Burne P, Furmaniak J, Smith BR. Sensitive non-isotopic assays for autoantibodies to IA-2 and to a combination of both IA-2 and GAD65. Clin Chim Acta. 2005 Jul 1;357 (1):74-83
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