ADMA ELISA
| Other names: Asymmetric Dimethylarginine | Distributed product | ||||
| Product: | Size: | ||||
|---|---|---|---|---|---|
| REA201/96 (regulatory status: IVD CE) | 96 wells (1 kit) | ||||
Files:
Datasheet PDF (IVD CE)MSDS (IVD CE)
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Product details
Summary
The vascular endothelium plays a central role in the regulation of vascular structure and function, mainly due to the formation of endothelium-derived nitric oxide (NO). NO is formed by the enzyme NO synthetase (NOS) from the amino acid precursor L-arginine. NOS activity can be downregulated by ADMA, an endogenous inhibitor of NOS. Elevated ADMA levels in plasma have been found in clinical studies including patients with hypercholesterolemia, hypertension, chronic heart failure, chronic renal failure and other internal disorders. ADMA may have diagnostic relevance as a novel cardiovascular risk marker.
Features
- For in vitro use only.
- Disposable gloves should be used.
- Material of animal origin used in the preparation of the kit has been obtained from animals certified as healthy but these materiále should be handled as potentially infectious.
Research topic
Blood pressure regulation and NO metabolism
Assay format
Competitive ELISA, Immobilized antigen
Applications
Plasma-EDTA, Serum
Sample requirements
20 μl
Storage/Shipping
Store the kit at 2–8 °C.
Calibration Curve
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Calibration range
0.1 – 5.0 µmol/l
Limit of detection
0.05 μmol/l
Intra-assay
CV = 6.0 %
Inter-assay
CV = 9.5 %
Spiking Recovery
CV = 95 %
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