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Products\Immunoassays\GAD Autoantibody Human ELISA:
GAD Autoantibody Human ELISA
| Other names: | Glutamic Acid Decarboxylase, GAD65, Anti-GAD, GADAb | ||
|---|---|---|---|
| Cat. No.: |
 RGDE/96R |
Regulatory status: RUO | |
| Size: | 96 wells (1 kit) | | | |
| Files: | Datasheet PDF (RUO) | ||
| Legend: | new product discount |
 temporarily out of stock order in advance |
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Research topic
Autoimmunity, Diabetology
Summary
Autoantibodies to pancreatic beta cell antigens are important serological markers of type 1 diabetes mellitus (type 1 DM). The antigens recognised by these antibodies include insulin, glutamic acid decarboxylase (GAD65 kDa isoform) and an islet cell antigen IA-2 or ICA-512.
Assay format
Sandwich ELISA, Biotin-labelled antibody
Sample requirements
100 μl
Applications
Serum
Calibration range
0 – 2000 U/ml
Limit of detection
0.06 U/ml
Intra-assay
CV = 7.9%
Inter-assay
CV = 5.5%
References to summary
- Brooking H, Ananieva-Jordanova R, Arnold C, Amoroso M, Powell M, Betterle C, Zanchetta R, Furmaniak J, Smith BR. A sensitive non-isotopic assay for GAD65 autoantibodies. Clin Chim Acta. 2003 May;331 (1-2):55-9
- Chen S, Willis J, Maclean C, Ananieva-Jordanova R, Amoroso MA, Brooking H, Powell M, Collins A, Bennett S, Mitchell S, Burne P, Furmaniak J, Smith BR. Sensitive non-isotopic assays for autoantibodies to IA-2 and to a combination of both IA-2 and GAD65. Clin Chim Acta. 2005 Jul 1;357 (1):74-83
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