Matrix Metalloproteinase-1 (MMP-1) Human ELISA

Summary

Matrix metalloproteinase-1 (MMP-1) is also known as collagenase. Matrix metalloproteinases (MMPs) are zinc-dependent proteases that degrade extrMMP-1llular matrix proteins. The MMPs comprise a family of at least 20 proteolytic enzymes that play an essential role in tissue remodeling. Matrix metalloproteinase-1 (MMP-1) plays an important role in the degradation of collagen in inflammatory diseases.1 MMP1 (interstitial collagenase), MMP9 (gelatinase B) and MMP12 (macrophage elastase) are thought to be important in the development of emphysema.2 Smoking-induced MMP-1 might be important in the skin-ageing effects of tobacco smoking.3 The standard product used in this kit is human MMP-1 with the molecular mass of 51–53KDa. The detected MMP-1 includes zymogen and active enzyme.

Research topic

Others

Assay format

Sandwich ELISA, Biotin-labelled antibody

Applications

Body fluids, Plasma, Serum, Tissue lysates

Storage/Shipping

Store at 4°C for frequent use, at –20°C for infrequent use. Avoid multiple freeze-thaw cycles (Shipped with wet ice.)

Calibration Curve

Calibration range

156 – 10 000 pg/ml

Limit of detection

< 20 pg/ml

By research topic:

• Others

By molecule:

• Matrix Metalloproteinase-1 (MMP-1)