MPO Human ELISA
| Other names: | Myeloperoxidase | ||
|---|---|---|---|
| Cat. No.: | RHK324R | Regulatory status: RUO | |
| Size: | 2 x 96 wels(1 kit) | | | |
| Files: | Datasheet PDF (RUO) | ||
| Legend: |  new product discount |
 temporarily out of stock order in advance |
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Research topic
Cardiovascular disease, Infection and inflammation
Storage/Shipping
+4°C/ Wet ice
Summary
Myeloperoxidase (MPO) is a glycoprotein with a alpha2beta2 heteromultimer expressed in all cells of the myeloid linage. MPO is abundantly present in azurophilic granules of polymorphonuclear neutrophils. It is an important enzyme used during phagocytic lysis of engulfed foreign particles which takes part in the defense of the organism through production of hypochlorous acid (HOCl), a potent oxidant. MPO is rapidly released by activated polymorphonuclear neutrophils. Involvement of MPO has been described in numerous diseases such as atherosclerosis, lung cancer, Alzheimer's disease and multiple sclerosis. Autoimmune antibodies to MPO are involved in Wegener’s disease. Since the discovery of MPO deficiency, initially regarded as rare and restricted to patients suffering from severe infections, MPO has attracted more clinical attention.
Assay format
Sandwich ELISA, Biotin-labelled antibody
Sample requirements
100 µl/well
Applications
Cell culture medium, Plasma-Citrate, Plasma-EDTA, Plasma-Heparin, Sputum
Calibration Curve
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Calibration range
0.4 to 100 ng/ml
Limit of detection
0.4 ng/ml
Spiking Recovery
40 ng/ml
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