Resistin Human ELISA

Summary

Resistin, a product of the RSTN gene, is a peptide hormone belonging to the class of cysteine-rich secreted proteins which is termed the RELM family, and is also described as ADSF (Adipose Tissue-Specific Secretory Factor) and FIZZ3 (Found in Inflammatory Zone). Human resistin contains 108 amino acids as a prepeptide, and its hydrofobic signal peptide is cleaved before its secretion. Resistin circulates in human blood as a dimeric protein consisting of two 92 amino acid polypeptides, which are disulfide-linked via Cys26. Resistin may be an important link between obesity and insulin resistance. Mouse resistin, specifically produced and secreted by adipocyte, acts on skeletal muscle myocytes, hepatocytes and adipocytes themselves so that it reduces their sensitivity to insulin. Steppan et al. have suggested that resistin suppresses the ability of insulin to stimulace glucose uptake. They have also suggested that resistin is present at elevated levels in blood of obese mice, and is down regulated by fasting and antidiabetic drugs. Way et al., on the other hand, have found that resistin expression is severly suppressed in obesity and is stimulated by several antidiabetic drugs. Other studies have shown that mouse resistin increases during the differentiation of adipocytes, but it also seems to inhibit adipogenesis. In contrast, the human adipogenic differentiation is likely to be associated with a down regulation of resistin gene expression. Recent studies have shown that human resistin is expressed also in macrophages and may be a novel link between inflammation and insulin resistance.

Features

• European Union: for in vitro diagnostic use

Rest of the world: for research use only!

• The total assay time is less than 4 hours
• The kit measures total resistin in serum and plasma (EDTA, citrate, heparin)
• Assay format is 96 wells
• Quality Controls are human serum based
• Standard is recombinant protein based
• Components of the kit are provided ready to use, concentrated or lyophilized

Research topic

Energy metabolism and body weight regulation

Assay format

Sandwich ELISA, Biotin-labelled antibody

Applications

Plasma-Citrate, Plasma-EDTA, Plasma-Heparin, Serum

Sample requirements

35 µl/well

Storage/Shipping

Store the kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Curve

Calibration range

1 – 50 ng/ml

Limit of detection

0.012 ng/ml

Intra-assay (Within-Run, n=8)

CV = 5.9 %

Inter-assay (Run-to-Run, n=5)

CV = 7.6 %

Spiking Recovery

91.0 %

Dilution Linearity

96.1 %

Cross-Reactivity

References to this product

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• Stejskal D, Proskova J, Adamovska S, Jurakova R, Bartek J. Preliminary experience with resistin assessment in common population. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. Dec;146(2):47-9 (2002)
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References to summary

• Meier U, Gressner AM: Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin. Clin Chem; 50(9):1511–25 (2004)
• Steppan CM, Lazar MA: The current biology of resistin. J Intern Med; 255(4):439–47 (2004)
• Kershaw EE, Flier JS: Adipose tissue as an endocrine organ. J Clin Endocrinol Metab; 89(6):2548–56 (2004)
• Fasshauer M, Paschke R: Regulation of adipocytokines and insulin resistance. Diabetologia; 46(12):1594–603 (2003)
• Steppan CM, Lazar MA: Resistin and obesity-associated insulin resistance. TRENDS in Endocrinology and Metabolism. 13 (1), 18–23, (2002)
• Hartman HB, Lazar MA at al.: Mechanisms Regulating Adipocyte Expression of Resistin. The Journal of Biological Chemistry; 277 (22), 19754–19761, (2002)
• Banerjee RR, Lazar MA: Dimerization of resistin and resistin–like moleules is determined by a single cystein. The Journal of Biological Chemistry; 276, 25970–25973, (2001)
• Steppan C.M. et al.: The Hormone Links Obesity to Diabetes. Nature; 409, 307–312, (2001)
• Way J.M. et al.: Adipose Tissue Resistin Expression Is Severly Suppressed in Obesity and Stimulated by Peroxisome Proliferator-activated Receptor g Agonists. The Journal of Biological Chemistry; 276 (28), 25651–25653, (2001)

By research topic:

• Energy metabolism and body weight regulation

By molecule:

• Resistin

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