VEGFR-1/FLT-1 Human ELISA

Summary

VEGFR1, also known as FMS-related tyrosine kinase 1(FLT1). Oncogene FLT belongs to the src gene family and is related to oncogene ROS . Like other members of this family, it shows tyrosine protein kinase activity that is important for the control of cell proliferation and differentiation. FLT is mapped to 13q12. VEGF receptor 1 signaling is essential for osteoclast development and bone marrow formation in colony-stimulating factor 1-deficient mice. The standard product used in this kit is recombinant human VEGFR1, consisting of 905 amino acids with the molecular mass of 100KDa

Research topic

Cytokines and chemokines and related molecules

Assay format

Sandwich ELISA, HRP-labelled antibody

Applications

Body fluids, Cell culture supernatant, Plasma-Citrate, Plasma-EDTA, Plasma-Heparin, Serum, Tissue lysates

Storage/Shipping

Store at 4℃ for frequent use, at –20℃ for infrequent use. Avoid multiple freeze-thaw cycles (Shipped with wet ice.)

Calibration Curve

Calibration range

156 – 10 000 pg/ml

Limit of detection

< 4 pg/ml

References to summary

• Imbert A, Rosnet O, Marchetto S, Ollendorff V, Birnbaum D, Pebusque MJ. Characterization of a yeast artificial chromosome from human chromosome band 13q12 containing the FLT1 and FLT3 receptor-type tyrosine kinase genes. Cytogenet Cell Genet. 1994;67 (3):175-7
• Shibuya M, Ikeda K, Noda T, Amizuka N, Hayashi S, Hiratsuka S, Kondo T, Niida S. VEGF receptor 1 signaling is essential for osteoclast development and bone marrow formation in colony-stimulating factor 1-deficient mice. Proc Natl Acad Sci U S A. 2005 Sep 27;102 (39):14016-21

By research topic:

• Cytokines and chemokines and related molecules

By molecule:

• VEGF-R1/FLT-1

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