Adiponectin Human E. coli

Introduction to the Molecule

Adiponectin, also referred to as Acrp30, AdipoQ and GBP-28, is a recently discovered 244 aminoacid protein, the product of the apM1 gene, which is physiologically active and specifically and highly expressed in adipose cells. The protein belongs to the soluble defence collagen superfamily; it has a collagen-like domain structurally homologous with collagen VIII and X and complement factor C1q-like globular domain. Adiponectin forms homotrimers, which are the building blocks for higher order complexes found circulating in serum. Together, these complexes make up approximately 0.01% of total serum protein. Adiponectin receptors AdipoR1 and AdipoR2 have been recently cloned; AdipoR1 is abundantly expressed in skeletal muscle, whereas AdipoR2 is predominantly expressed in the liver. Paradoxically, adipose tissue-expressed adiponectin levels are inversely related to the degree of adiposity. Adiponectin concentrations correlate negatively with glucose, insulin, triglyceride concentrations, liver fat content and body mass index and positively with high-density lipoprotein-cholesterol levels, hepatic insulin sensitivity and insulin-stimulated glucose disposal. Adiponectin has been shown to increase insulin sensitivity and decrease plasma glucose by increasing tissue fat oxidation. Of particular interest is that low adiponectin serum levels predict type 2 diabetes independent of other risk factors. Adiponectin also inhibits the inflammatory processes of atherosclerosis suppressing the expression of adhesion and cytokine molecules in vascular endothelial cells and macrophages, respectively. This adipokine plays a role as a scaffold of newly formed collagen in myocardial remodelling after ischaemic injury and also stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signalling in endothelial cells. Low serum adiponectin levels are found in patients with coronary artery disease. Moreover, high circulating levels of adiponectin are associated with decreased risk of myocardial infarction, independent of other factors. Altogether, adiponectin has the potential to become a clinically relevant parameter to be measured routinely in subjects at risk for type 2 diabetes, atherosclerosis and the metabolic syndrome.

Research topic

Energy metabolism and body weight regulation

Description

Total 242 AA. MW: 26.4 kDa (calculated). N-Terminal His-tag, 12 extra AA (highlighted).

Amino Acid Sequence

Source

E. coli

Purity

>95%

SDS-PAGE gel

12% SDS-PAGE separation of Human Adiponectin (E.coli) 1. M.W. marker – 14, 21, 31, 45, 66, 97 kDa 2. reduced and heated sample, 5μg/lane 3. non-reduced and non-heated sample, 5μg/lane

Endotoxin

< 1.0 EU/ug

Formulation

Filtered (0,4 μm) and lyophilized in 0.5 mg/mL in 0.02M Tris buffer pH 7.5, 0.15M NaCl

Reconstitution

Add deionized water to prepare a working stock solution of approximately 0.5 mg/mL and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

Storage, Stability/Shelf Life

Store lyophilized protein at –20°C. Lyophilized protein remains stable until the expiry date when stored at –20°C. Aliquot reconstituted protein to avoid repeated freezing/thawing cycles and store at –80°C for long term storage. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after one week at 4°C.

Find out more on biovendor.com

• Adiponectin Isomers in BioVendor News
• Adiponectin isoforms in BioVendor Reviews

Quality Control Test

BCA to determine quantity of the protein.

SDS PAGE to determine purity of the protein.

LAL to determine quantity of endotoxin.

Applications

ELISA, Western blotting

Note

This product is intended for research use only. The Certificate of Analysis is available on www.biovendor.com

References

• Adachi M, Brenner DA. High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase. Hepatology. 2008 Feb;47 (2):677-85
• Andersen M, Flyvbjerg A, Hagen C, Hermann AP, Henriksen JE, Andersen KK, Hojlund K, Frystyk J, Glintborg D. Total and high molecular weight (HMW) adiponectin levels and measures of glucose and lipid metabolism following pioglitazone treatment in a randomized placebo-controlled study in polycystic ovary syndrome. Clin Endocrinol (Oxf). 2008 Feb;68 (2):165-74
• Asada K, Yoshiji H, Noguchi R, Ikenaka Y, Kitade M, Kaji K, Yoshii J, Yanase K, Namisaki T, Yamazaki M, Tsujimoto T, Akahane T, Uemura M, Fukui H. Crosstalk between high-molecular-weight adiponectin and T-cadherin during liver fibrosis development in rats. Int J Mol Med. 2007 Nov;20 (5):725-9
• Aslanidis C, Schaeffler A, Piso P, Langmann T, Schmitz G, Neumeier M, Scholmerich J, Eggenhofer E, Sigruener A, Weigert J, Buechler C, Schlitt HJ, Weiss TS. High molecular weight adiponectin reduces apolipoprotein B and E release in human hepatocytes. Biochem Biophys Res Commun. 2007 Jan 12;352 (2):543-8
• Berg AH, Combs TP, Du X, Brownlee M, Scherer PE. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med. 2001; 7:947-953.
• Berg AH, Combs TP, Scherer PE. ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends Endocrinol Metab. 2002;13:84-89.
• Buechler C, Aslanidis C, Schmitz G, Liebisch G, Dada A, Schaffler A, Wanninger J, Wurm S, Weigert J, Neumeier M, Schober F. Low molecular weight adiponectin negatively correlates with the waist circumference and monocytic IL-6 release. Biochem Biophys Res Commun. 2007 Oct 5;361 (4):968-73
• Charlesworth JA, Shen Y, Hughes JT, Peake PW. Glycosylation of human adiponectin affects its conformation and stability. J Mol Endocrinol. 2007 Jul;39 (1):45-52
• Chen H, Montagnani M, Funahashi T, Shimomura I, Quon MJ. Adiponectin stimulates production of nitric oxide in vascular endothelial cells. J Biol Chem. 2003;278:45021-45026.
• Fisher FF, Trujillo ME, Hanif W, Barnett AH, McTernan PG, Scherer PE, Kumar S. Serum high molecular weight complex of adiponectin correlates better with glucose tolerance than total serum adiponectin in Indo-Asian males. Diabetologia. 2005 Jun;48 (6):1084-7
• Flyvbjerg A, Heuck C, Wolthers OD, Frystyk J, Andersen KK. Gender differences of oligomers and total adiponectin during puberty: a cross-sectional study of 859 Danish school children. J Clin Endocrinol Metab. 2007 May;92 (5):1857-62
• Grinspoon SK, Ahima RS, Lo J, Jackson MB, Torriani M, Canavan B, Bernstein LE. Effects of TNF-alpha neutralization on adipocytokines and skeletal muscle adiposity in the metabolic syndrome. Am J Physiol Endocrinol Metab. 2007 Jul;293 (1):E102-9
• Hattori Y, Hattori S, Akimoto K, Nishikimi T, Suzuki K, Matsuoka H, Kasai K. Globular adiponectin activates nuclear factor-kappaB and activating protein-1 and enhances angiotensin II-induced proliferation in cardiac fibroblasts. Diabetes. 2007 Mar;56 (3):804-8
• Hawkins M, Scherer PE, Weaver C, Kwon E, Pajvani UB, Kishore P, Li W, Tonelli J. Mechanisms of early insulin-sensitizing effects of thiazolidinediones in type 2 diabetes. Diabetes. 2004 Jun;53 (6):1621-9
• Hendriks HF, Helander A, Spranger J, Bobbert T, Pelsers M, Kok FJ, van Loon LJ, Beulens JW. The effect of moderate alcohol consumption on adiponectin oligomers and muscle oxidative capacity: a human intervention study. Diabetologia. 2007 Jul;50 (7):1388-92
• Hug C, Lodish HF. The role of the adipocyte hormone adiponectin in cardiovascular disease. Curr Opin Pharmacol. 2005 Apr;5 (2):129-34
• Itoh H, Saito I, Hirose H, Seino Y. High molecular weight multimer form of adiponectin as a useful marker to evaluate insulin resistance and metabolic syndrome in Japanese men. Metabolism. 2007 Nov;56 (11):1493-9
• Itoh H, Saito I, Yamamoto Y, Hirose H, Nakatani H. Significance of leptin and high-molecular weight adiponectin in the general population of Japanese male adolescents. Metabolism. 2008 Feb;57 (2):157-62
• Kadowaki T, Nagai R, Imai Y, Ebinuma H, Miyazaki O, Yago H, Yamauchi T, Horikoshi M, Hara K. Measurement of the high-molecular weight form of adiponectin in plasma is useful for the prediction of insulin resistance and metabolic syndrome. Diabetes Care. 2006 Jun;29 (6):1357-62
• Kadowaki T, Nagai R, Kimura S, Froguel P, Vasseur F, Hada Y, Hara K, Kita S, Uchida S, Ito Y, Kamon J, Yamauchi T, Waki H. Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin. J Biol Chem. 2003 Oct 10;278 (41):40352-63
• Kadowaki T, Yamauchi T, Hara K, Yago H, Miyazaki O, Ebinuma H. A novel ELISA system for selective measurement of human adiponectin multimers by using proteases. Clin Chim Acta. 2006 Oct;372 (1-2):47-53
• Kelesidis T, Kratzsch J, Fasshauer M, Kralisch S, Williams CJ, Mantzoros CS, Bluher M, Brennan AM. Total and high-molecular weight adiponectin in relation to metabolic variables at baseline and in response to an exercise treatment program: comparative evaluation of three assays. Diabetes Care. 2007 Feb;30 (2):280-5
• Kobayashi H, Ouchi N, Kihara S, Walsh K, Kumada M, Abe Y, et al. Selective suppression of endothelial cell apoptosis by the high molecular weight form of adiponectin. Circulation research. 2004 Mar 5;94(4):e27-31.
• Kobayashi H, Ouchi N, Kihara S, Walsh K, Kumada M, Abe Y, Funahashi T, Matsuzawa Y, Ferre P. Selective Suppression of Endothelial Cell Apoptosis by the High Molecular Weight.
• Kumar S, Scherer PE, Kusminski CM, McTernan PG, Kos K, Schraw T, Ahima R, O'Hare JP. Adiponectin complexes in human cerebrospinal fluid: distinct complex distribution from serum. Diabetologia. 2007 Mar;50 (3):634-42
• Lam KS, Cooper GJ, Tse C, Lam MC, Chen B, Zhang J, Tan KC, Wang Y, Hoo RL, Chan KW, Xu A. Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes. J Biol Chem. 2005 May 6;280 (18):18073-80
• Lau GK, Kwong YL, Lam KS, Xu A, Luk JM, Fan ST, Lo CM, Leung N, Lu L, Leung KW, Yueng YH, Chan W, Lee NP, Zhang HY, Hui CK. Serum adiponectin is increased in advancing liver fibrosis and declines with reduction in fibrosis in chronic hepatitis B. J Hepatol. 2007 Aug;47 (2):191-202
• Lee DH, Suzuki S, Wilson-Kubalek EM, Wert D, Tsao TS. The oligomeric structure of high molecular weight adiponectin. FEBS Lett. 2007 Mar 6;581 (5):809-14
• Lodish HF, Tsao TS, Bogan JS, Ahmad NS, Wang J, Hug C. T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin. Proc Natl Acad Sci U S A. 2004 Jul 13;101 (28):10308-13
• Loi KW, Kelly JJ, Charlesworth JA, Shen YY, Peake PW. Up-regulation of adiponectin, its isoforms and receptors in end-stage kidney disease. Nephrol Dial Transplant. 2007 Jan;22 (1):171-8
• Luley C, Westphal S. Preferential increase in high-molecular weight adiponectin after niacin. Atherosclerosis. 2008 May;198 (1):179-83
• Luo N, Wallace P, Lara-Castro C, Garvey WT, Klein RL. Adiponectin multimeric complexes and the metabolic syndrome trait cluster. Diabetes. 2006 Jan;55 (1):249-59
• Macdonald GA, Jones A, Charlton HK, Stephens T, Prins JB, Richards AA, Whitehead JP. Adiponectin multimerization is dependent on conserved lysines in the collagenous domain: evidence for regulation of multimerization by alterations in posttranslational modifications. Mol Endocrinol. 2006 Jul;20 (7):1673-87
• Maggi D, Andraghetti G, Adami GF, Briatore L, Salani B, Cordera R. High-molecular weight adiponectin isoforms increase after biliopancreatic diversion in obese subjects. Obesity (Silver Spring). 2006 Sep;14 (9):1511-4
• Matsuda M, Shimomura I, et al. Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis. J Biol Chem. 2002;277:37487-37491.
• Matsuzawa Y, Funahashi T, Abe Y, Kumada M, Walsh K, Kihara S, Ouchi N, Kobayashi H. Selective suppression of endothelial cell apoptosis by the high molecular weight form of adiponectin. Circ Res. 2004 Mar 5;94 (4):e27-31
• Matsuzawa Y, Funahashi T, Shimomura I, Okamoto Y, Arita Y, Ouchi N, Matsumoto S, Kawamoto T, Sumitsuji S, Hayashi N, Kuroda Y, Tamba S, Nakagawa Y, Okada T, Hiuge A, Fujita K, Kumada M, Sonoda M, Kihara S, Komura N. Clinical significance of high-molecular weight form of adiponectin in male patients with coronary artery disease. Circ J. 2008 Jan;72 (1):23-8
• Morkrid L, Odden N. High molecular weight adiponectin dominates in cord blood of newborns but is unaffected by pre-eclamptic pregnancies. Clin Endocrinol (Oxf). 2007 Dec;67 (6):891-6
• O'Rahilly S, Gorden P, Scherer PE, Wareham NJ, Dunger DB, Cochran EK, Luan J, Schraw T, Soos MA, Burling K, Halberg NH, Semple RK. Paradoxical elevation of high-molecular weight adiponectin in acquired extreme insulin resistance due to insulin receptor antibodies. Diabetes. 2007 Jun;56 (6):1712-7
• Ogihara T, Funahashi T, Kawano Y, Rakugi H, Kihara S, Suzuki Y, Kumada M, Horio T, Iwashima Y. Adiponectin and renal function, and implication as a risk of cardiovascular disease. Am J Cardiol. 2006 Dec 15;98 (12):1603-8
• Okamoto Y, Kihara S, et al. Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice. Circulation. 2002;106:2767-2770.
• Okumura K, Murohara T, Numaguchi Y, Cheng XW, Murakami R, Murakami H, Ogawa Y, Matsui H, Torigoe M. Impact of the high-molecular-weight form of adiponectin on endothelial function in healthy young men. Clin Endocrinol (Oxf). 2007 Aug;67 (2):276-81
• Olefsky JM, Kahn SE, Utzschneider KM, Xiang AH, Knopps A, Wu M, Wagner JA, Berger JP, Doebber T, Combs TP, Rajala MW, Hawkins M, Pajvani UB, Scherer PE, Buchanan TA. Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity. J Biol Chem. 2004 Mar 26;279 (13):12152-62
• Owens RJ, Kern PA, Ono F, Rasouli N, Banga A, Bodles AM. Pioglitazone increases secretion of high-molecular-weight adiponectin from adipocytes. Am J Physiol Endocrinol Metab. 2006 Nov;291 (5):E1100-5
• Pajvani UB, Du X, Combs TP, Berg AH, Rajala MW, Schulthess T, Engel J, Brownlee M, Scherer PE. Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity. J Biol Chem. 2003; 278:9073-85.
• Pajvani UB, Du X, Combs TP, Berg AH, Rajala MW, Schulthess T, Engel J, Brownlee M, Scherer PE. Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity. J Biol Chem. 2003; 278:9073-85.
• Papademetris X, Kahn BB, Zemany L, Befroy D, Cline GW, Yonemitsu S, Solomon G, Bilz S, Savage DB, Dufour S, Petersen KF, Rothman DL, Shulman GI. The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome. Proc Natl Acad Sci U S A. 2007 Jul 31;104 (31):12587-94
• Purnell JQ, Svetkey LP, Newgard CB, Muehlbauer M, Haqq AM, Freemark MS, Grambow SC. Altered distribution of adiponectin isoforms in children with Prader-Willi syndrome (PWS): association with insulin sensitivity and circulating satiety peptide hormones. Clin Endocrinol (Oxf). 2007 Dec;67 (6):944-51
• Ram A, Faigin M, Yaroslavsky A, Stein D, Kanety H, Pariente C, Modan-Moses D, Hemi R, Yissachar E, Loewenthal R. Modulation of adiponectin and leptin during refeeding of female anorexia nervosa patients. J Clin Endocrinol Metab. 2007 May;92 (5):1843-7
• Retnakaran R, Hanley AJ, Zinman B, Maguire G, Sermer M, Connelly PW, Hamilton JK, Ong GK. Maternal serum adiponectin and infant birthweight: the role of adiponectin isoform distribution. Clin Endocrinol (Oxf). 2007 Jul;67 (1):108-14
• Retnakaran R, Liu Y, Shaw C, Tungtrongchitr R, Sweeney G, Hanley A. Total and high molecular weight but not trimeric or hexameric forms of adiponectin correlate with markers of the metabolic syndrome and liver injury in Thai subjects. J Clin Endocrinol Metab. 2007 Nov;92 (11):4313-8
• Scherer PE, Hawkins M, Halberg N, Wang ZV, Schraw T. Plasma adiponectin complexes have distinct biochemical characteristics. Endocrinology. 2008 May;149 (5):2270-82
• Scherer PE, Konrad RJ, Schraw T, Havel PJ, Wolfe BM, Stanhope KL, Swarbrick MM, Davis RA, Alborn WE, Ji S, Wang J, Sloan JH, Xiao Q, Songer T, Sinha MK, Mistry JS. Analytical validation and biological evaluation of a high molecular-weight adiponectin ELISA. Clin Chem. 2007 Dec;53 (12):2144-51
• Scherer PE, Rizza RA, Pajvani UB, Basu R. Selective downregulation of the high molecular weight form of adiponectin in hyperinsulinemia and in type 2 diabetes: differential regulation from nondiabetic subjects. Diabetes. 2007 Aug;56 (8):2174-7
• Schraw T, Wang ZV, Halberg N, Hawkins M, Scherer PE. Plasma adiponectin complexes have distinct biochemical characteristics. Endocrinology. 2008 May;149 (5):2270-82
• Sermer M, Maguire G, Connelly PW, Retnakaran R, Hanley AJ, Zinman B. Decreased high-molecular-weight adiponectin in gestational diabetes: implications for the pathophysiology of Type 2 diabetes. Diabet Med. 2007 Mar;24 (3):245-52
• Shen Y, Campbell LV, Charlesworth JA, Peake PW, Kriketos AD. The metabolism of isoforms of human adiponectin: studies in human subjects and in experimental animals. Eur J Endocrinol. 2005 Sep;153 (3):409-17
• Shirahata A, Asayama K, Kubo K, Dobashi K, Araki S. High molecular weight, rather than total, adiponectin levels better reflect metabolic abnormalities associated with childhood obesity. J Clin Endocrinol Metab. 2006 Dec;91 (12):5113-6
• Shirasawa T, Sano H, Miyashita Y, Matsudaira T, Morimoto A, Nishimura R, Tajima N, Takahashi E. Ratio of high-, medium-, and low-molecular weight serum adiponectin to the total adiponectin value in children. J Pediatr. 2007 Nov;151 (5):545-7, 547.e1-2
• Stanhope KL, Austrheim-Smith IT, Swarbrick MM, Wolfe BM, Havel PJ, Van Loan MD, Ali MR. Circulating concentrations of high-molecular-weight adiponectin are increased following Roux-en-Y gastric bypass surgery. Diabetologia. 2006 Nov;49 (11):2552-8
• Taketani Y, Yano T, Harada M, Morimoto C, Hirata T, Hirota Y, Tajima T, Koga K, Osuga Y, Takemura Y. Selective increase in high molecular weight adiponectin concentration in serum of women with preeclampsia. J Reprod Immunol. 2007 Feb;73 (1):60-5
• Tobe T, Tomita M, Negoro T, Tanioka T, Tsushima M, Akiyama H, Yoshimi A, Tajima S, Nakano Y. A novel enzyme-linked immunosorbent assay specific for high-molecular-weight adiponectin. J Lipid Res. 2006 Jul;47 (7):1572-82
• Tsai SH, Chou DT, Chang CP, Hsieh MS, Chen L, Chen TH. Evidence for a protective role for adiponectin in osteoarthritis. Biochim Biophys Acta. 2006 Aug;1762 (8):711-8
• Tsutamoto T, Tanaka T, Sakai H, Ishikawa C, Fujii M, Yamamoto T, Horie M. Total and high molecular weight adiponectin, haemodynamics, and mortality in patients with chronic heart failure. Eur Heart J. 2007 Jul;28 (14):1723-30
• von Eynatten M, Humpert PM, Bluemm A, Lepper PM, Hamann A, Allolio B, Nawroth PP, Bierhaus A, Dugi KA. High-molecular weight adiponectin is independently associated with the extent of coronary artery disease in men. Atherosclerosis. 2008 Jul;199 (1):123-8
• Waki H, Yamauchi T, Kamon J, Kita S, Ito Y, Hada Y, Uchida S, Tsuchida A, Takekawa S, Kadowaki T. Generation of globular fragment of adiponectin by leukocyte elastase secreted by monocytic cell line THP-1. Endocrinology. 2005 Feb;146(2):790-6. Epub 2004 Nov 4.
• Wang Y, Xu A, Knight C, Xu LY, Cooper GJ. Hydroxylation and glycosylation of the four conserved lysine residues in the collagenous domain of adiponectin. Potential role in the modulation of its insulin-sensitizing activity. J Biol Chem. 2002; 277:19521-19529.
• Wang Y, Xu A, Knight C, Xu LY, Cooper GJ. Hydroxylation and glycosylation of the four conserved lysine residues in the collagenous domain of adiponectin. Potential role in the modulation of its insulin-sensitizing activity. J Biol Chem. 2002; 277:19521-19529.
• Whitehead JP, Mowry BJ, Richards AA, Newell F, Jones AL, Wang AY, Hickman IJ, Prins JB, Macdonald GA. Olanzapine treatment is associated with reduced high molecular weight adiponectin in serum: a potential mechanism for olanzapine-induced insulin resistance in patients with schizophrenia. J Clin Psychopharmacol. 2006 Jun;26 (3):232-7
• Xu A, Cooper GJ, Mak WW, Hoo RC, Lam MC, Lam JB, Chan KW, Chan L, Lam KS, Wang Y. Post-translational modifications of the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high molecular weight oligomeric complex. J Biol Chem. 2006 Jun 16;281 (24):16391-400
• Xu A, Cooper GJ, Xu LY, Lu G, Xu JY, Lam KS, Wang Y. Adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization-dependent manner. J Biol Chem. 2005 May 6;280 (18):18341-7
• Xu A, Wang Y, Keshaw H, Xu LY, Lam KS, Cooper GJ. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J Clin Invest. 2003; 112:91-100.
• Yamane K, Nakashima R, Nakanishi S, Koide J, Oki K. Fenofibrate increases high molecular weight adiponectin in subjects with hypertriglyceridemia. Endocr J. 2007 Jun;54 (3):431-5
• Yamauchi T, Kamon J, et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med. 2001;7:941-946.
• Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, Yamashita S, Noda M, Kita S, Ueki K, Eto K, Akanuma Y, Froguel P, Foufelle F, Ferre P, Carling D, Kimura S, Nagai R, Kahn BB, Kadowaki T. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med. 2002; 8:1288-1295.

By research topic:

• Energy metabolism and body weight regulation

By molecule:

• Adiponectin

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