Gamma Enolase Human

Introduction to the Molecule

Enolase (2-phosphoglycerate hydrolyase or phosphopyruvate hydrates) is a glycolytic enzyme that catalyzes the dehydration and conversion of 2-phosphoglycerate to phosphoenolpy­ruvate. It comprises three distinct subunits, α, β and γ. The γγ and αγ dimeric forms of enolase, referred to as neuron-specific enolase(NSE), are localized mainly in neurons and neuroectodermal tissue. NSE has a high stability in biological fluids and can easily diffuse to the extracellular medium and cerebrospinal fluid(CSF) when neuronal membranes are injured. NSE is used clinically as a sensitive and useful marker of neuronal damage in several neurological disorders including stroke, hypoxic brain damage, status epilepticus, Creutzfeldt- Jakob disease, and herpetic encephalitis.

Research topic

Neural tissue damage markers

Description

Total 436 AA. MW: 47.59 kDa (calculated). C-Terminal His-tag

Amino Acid Sequence

Source

HeLa, COS7

Formulation

Frozen in production medium.

Reconstitution

Defrost at ambient temperature.

Storage, Stability/Shelf Life

Store frozen at –20 °C. Stable until expiry date.

Quality Control Test

SDS-PAGE

Applications

In vitro diagnostic

By research topic:

• Neural tissue damage markers

By molecule:

• Gamma Enolase