S100B Human (E.coli)

Introduction to the Molecule

S-100B protein is a member of highly homologous acidic calcium and zinc binding proteins family (S100 family) that possess two EF-hand motifs. S100B is a  homodimer with the molecular weight 21 kDa. S100B is abundant in the nervous system where it is predominantly expressed in astrocytes, oligodendrocytes and Schwann cells. S100B is released from brain tissue into cerebrospinal fluid (CSF) and blood following brain damage of different origin, i.e., brain infarction, intracerebral or subarachnoidal hemorrhage, neurotrauma and large intracerebral tumors. It is documented a relationship between degree of cell damage and S100B levels in CSF. Also patients with progressive melanoma disease show elevated serum concentrations of S100B.

Research topic

Neural tissue damage markers

Source

E. coli

Storage, Stability/Shelf Life

S100B is supplied with a vial of storage buffer (20mM HEPES, pH7.0/10% Glycerol). Store at –80°C.

By research topic:

• Neural tissue damage markers

By molecule:

• S100B