Tumor Necrosis Factor - alpha Human (E.coli)

Introduction to the Molecule

TNF-α (17.5 kDa, 157 amino acid) is a non-glycosylated protein that is a potent lymphoid factor, which exerts cytotoxic effects on a wide range of tumor cells and other target cells. It is secreted by macrophages, monocytes, neutrophils, T-cells and NK-cells following their stimulation by bacterial lipopolysaccha­rides. TNF-α has been suggested to play a pro-inflammatory role and has been detected in synovial fluid of patients with rheumatoid arthritis.

Research topic

Cytokines and chemokines and related molecules, Energy metabolism and body weight regulation

Source

E. coli

Storage, Stability/Shelf Life

TNF- α is supplied with a vial of storage buffer (20mM Tris-Cl, pH 8.0/1mM EDTA). Store at –80°C.

By research topic:

• Cytokines and chemokines and related molecules
• Energy metabolism and body weight regulation

By molecule:

• TNF-alpha