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Adiponectin isoforms (6. References)

  • Kadowaki T, Yamauchi T, Hara K, Yago H, Miyazaki O, Ebinuma H. A novel ELISA system for selective measurement of human adiponectin multimers by using proteases. Clin Chim Acta. 2006 Oct;372 (1-2):47-53
  • Tobe T, Tomita M, Negoro T, Tanioka T, Tsushima M, Akiyama H, Yoshimi A, Tajima S, Nakano Y. A novel enzyme-linked immunosorbent assay specific for high-molecular-weight adiponectin. J Lipid Res. 2006 Jul;47 (7):1572-82
  • Berg AH, Combs TP, Scherer PE. ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends Endocrinol Metab. 2002;13:84-89.
  • Ogihara T, Funahashi T, Kawano Y, Rakugi H, Kihara S, Suzuki Y, Kumada M, Horio T, Iwashima Y. Adiponectin and renal function, and implication as a risk of cardiovascular disease. Am J Cardiol. 2006 Dec 15;98 (12):1603-8
  • Kumar S, Scherer PE, Kusminski CM, McTernan PG, Kos K, Schraw T, Ahima R, O'Hare JP. Adiponectin complexes in human cerebrospinal fluid: distinct complex distribution from serum. Diabetologia. 2007 Mar;50 (3):634-42
  • Xu A, Cooper GJ, Xu LY, Lu G, Xu JY, Lam KS, Wang Y. Adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization-dependent manner. J Biol Chem. 2005 May 6;280 (18):18341-7
  • Luo N, Wallace P, Lara-Castro C, Garvey WT, Klein RL. Adiponectin multimeric complexes and the metabolic syndrome trait cluster. Diabetes. 2006 Jan;55 (1):249-59
  • Macdonald GA, Jones A, Charlton HK, Stephens T, Prins JB, Richards AA, Whitehead JP. Adiponectin multimerization is dependent on conserved lysines in the collagenous domain: evidence for regulation of multimerization by alterations in posttranslational modifications. Mol Endocrinol. 2006 Jul;20 (7):1673-87
  • Okamoto Y, Kihara S, et al. Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice. Circulation. 2002;106:2767-2770.
  • Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, Yamashita S, Noda M, Kita S, Ueki K, Eto K, Akanuma Y, Froguel P, Foufelle F, Ferre P, Carling D, Kimura S, Nagai R, Kahn BB, Kadowaki T. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med. 2002; 8:1288-1295.
  • Chen H, Montagnani M, Funahashi T, Shimomura I, Quon MJ. Adiponectin stimulates production of nitric oxide in vascular endothelial cells. J Biol Chem. 2003;278:45021-45026.
  • Purnell JQ, Svetkey LP, Newgard CB, Muehlbauer M, Haqq AM, Freemark MS, Grambow SC. Altered distribution of adiponectin isoforms in children with Prader-Willi syndrome (PWS): association with insulin sensitivity and circulating satiety peptide hormones. Clin Endocrinol (Oxf). 2007 Dec;67 (6):944-51
  • Scherer PE, Sinha MK, Songer T, Xiao Q, Sloan JH, Wang J, Ji S, Alborn WE, Davis RA, Swarbrick MM, Stanhope KL, Wolfe BM, Havel PJ, Schraw T, Konrad RJ, Mistry JS. Analytical validation and biological evaluation of a high molecular-weight adiponectin ELISA. Clin Chem. 2007 Dec;53 (12):2144-51
  • Stanhope KL, Austrheim-Smith IT, Swarbrick MM, Wolfe BM, Havel PJ, Van Loan MD, Ali MR. Circulating concentrations of high-molecular-weight adiponectin are increased following Roux-en-Y gastric bypass surgery. Diabetologia. 2006 Nov;49 (11):2552-8
  • Matsuzawa Y, Tamba S, Nakagawa Y, Okada T, Hiuge A, Fujita K, Kumada M, Sonoda M, Kihara S, Kuroda Y, Hayashi N, Funahashi T, Shimomura I, Okamoto Y, Arita Y, Ouchi N, Matsumoto S, Kawamoto T, Sumitsuji S, Komura N. Clinical significance of high-molecular weight form of adiponectin in male patients with coronary artery disease. Circ J. 2008 Jan;72 (1):23-8
  • Olefsky JM, Scherer PE, Pajvani UB, Hawkins M, Rajala MW, Combs TP, Doebber T, Berger JP, Wagner JA, Wu M, Knopps A, Xiang AH, Utzschneider KM, Kahn SE, Buchanan TA. Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity. J Biol Chem. 2004 Mar 26;279 (13):12152-62
  • Asada K, Uemura M, Akahane T, Tsujimoto T, Yamazaki M, Namisaki T, Yanase K, Yoshii J, Kaji K, Kitade M, Ikenaka Y, Noguchi R, Yoshiji H, Fukui H. Crosstalk between high-molecular-weight adiponectin and T-cadherin during liver fibrosis development in rats. Int J Mol Med. 2007 Nov;20 (5):725-9
  • Sermer M, Maguire G, Connelly PW, Retnakaran R, Hanley AJ, Zinman B. Decreased high-molecular-weight adiponectin in gestational diabetes: implications for the pathophysiology of Type 2 diabetes. Diabet Med. 2007 Mar;24 (3):245-52
  • Grinspoon SK, Ahima RS, Lo J, Jackson MB, Torriani M, Canavan B, Bernstein LE. Effects of TNF-alpha neutralization on adipocytokines and skeletal muscle adiposity in the metabolic syndrome. Am J Physiol Endocrinol Metab. 2007 Jul;293 (1):E102-9
  • Tsai SH, Chou DT, Chang CP, Hsieh MS, Chen L, Chen TH. Evidence for a protective role for adiponectin in osteoarthritis. Biochim Biophys Acta. 2006 Aug;1762 (8):711-8
  • Yamane K, Nakashima R, Nakanishi S, Koide J, Oki K. Fenofibrate increases high molecular weight adiponectin in subjects with hypertriglyceridemia. Endocr J. 2007 Jun;54 (3):431-5
  • Flyvbjerg A, Heuck C, Wolthers OD, Frystyk J, Andersen KK. Gender differences of oligomers and total adiponectin during puberty: a cross-sectional study of 859 Danish school children. J Clin Endocrinol Metab. 2007 May;92 (5):1857-62
  • Waki H, Yamauchi T, Kamon J, Kita S, Ito Y, Hada Y, Uchida S, Tsuchida A, Takekawa S, Kadowaki T. Generation of globular fragment of adiponectin by leukocyte elastase secreted by monocytic cell line THP-1. Endocrinology. 2005 Feb;146(2):790-6. Epub 2004 Nov 4.
  • Hattori Y, Hattori S, Akimoto K, Nishikimi T, Suzuki K, Matsuoka H, Kasai K. Globular adiponectin activates nuclear factor-kappaB and activating protein-1 and enhances angiotensin II-induced proliferation in cardiac fibroblasts. Diabetes. 2007 Mar;56 (3):804-8
  • Charlesworth JA, Shen Y, Hughes JT, Peake PW. Glycosylation of human adiponectin affects its conformation and stability. J Mol Endocrinol. 2007 Jul;39 (1):45-52
  • Morkrid L, Odden N. High molecular weight adiponectin dominates in cord blood of newborns but is unaffected by pre-eclamptic pregnancies. Clin Endocrinol (Oxf). 2007 Dec;67 (6):891-6
  • Adachi M, Brenner DA. High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase. Hepatology. 2008 Feb;47 (2):677-85
  • Aslanidis C, Schlitt HJ, Buechler C, Weigert J, Sigruener A, Eggenhofer E, Scholmerich J, Neumeier M, Schmitz G, Langmann T, Piso P, Schaeffler A, Weiss TS. High molecular weight adiponectin reduces apolipoprotein B and E release in human hepatocytes. Biochem Biophys Res Commun. 2007 Jan 12;352 (2):543-8
  • Itoh H, Saito I, Hirose H, Seino Y. High molecular weight multimer form of adiponectin as a useful marker to evaluate insulin resistance and metabolic syndrome in Japanese men. Metabolism. 2007 Nov;56 (11):1493-9
  • Shirahata A, Asayama K, Kubo K, Dobashi K, Araki S. High molecular weight, rather than total, adiponectin levels better reflect metabolic abnormalities associated with childhood obesity. J Clin Endocrinol Metab. 2006 Dec;91 (12):5113-6
  • von Eynatten M, Humpert PM, Bluemm A, Lepper PM, Hamann A, Allolio B, Nawroth PP, Bierhaus A, Dugi KA. High-molecular weight adiponectin is independently associated with the extent of coronary artery disease in men. Atherosclerosis. 2008 Jul;199 (1):123-8
  • Maggi D, Andraghetti G, Adami GF, Briatore L, Salani B, Cordera R. High-molecular weight adiponectin isoforms increase after biliopancreatic diversion in obese subjects. Obesity (Silver Spring). 2006 Sep;14 (9):1511-4
  • Wang Y, Xu A, Knight C, Xu LY, Cooper GJ. Hydroxylation and glycosylation of the four conserved lysine residues in the collagenous domain of adiponectin. Potential role in the modulation of its insulin-sensitizing activity. J Biol Chem. 2002; 277:19521-19529.
  • Wang Y, Xu A, Knight C, Xu LY, Cooper GJ. Hydroxylation and glycosylation of the four conserved lysine residues in the collagenous domain of adiponectin. Potential role in the modulation of its insulin-sensitizing activity. J Biol Chem. 2002; 277:19521-19529.
  • Okumura K, Murohara T, Numaguchi Y, Cheng XW, Murakami R, Murakami H, Ogawa Y, Matsui H, Torigoe M. Impact of the high-molecular-weight form of adiponectin on endothelial function in healthy young men. Clin Endocrinol (Oxf). 2007 Aug;67 (2):276-81
  • Kadowaki T, Yamauchi T, Kamon J, Ito Y, Uchida S, Kita S, Hara K, Hada Y, Vasseur F, Froguel P, Kimura S, Nagai R, Waki H. Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin. J Biol Chem. 2003 Oct 10;278 (41):40352-63
  • Buechler C, Neumeier M, Weigert J, Wurm S, Wanninger J, Schaffler A, Dada A, Liebisch G, Schmitz G, Aslanidis C, Schober F. Low molecular weight adiponectin negatively correlates with the waist circumference and monocytic IL-6 release. Biochem Biophys Res Commun. 2007 Oct 5;361 (4):968-73
  • Retnakaran R, Hanley AJ, Zinman B, Maguire G, Sermer M, Connelly PW, Hamilton JK, Ong GK. Maternal serum adiponectin and infant birthweight: the role of adiponectin isoform distribution. Clin Endocrinol (Oxf). 2007 Jul;67 (1):108-14
  • Kadowaki T, Nagai R, Imai Y, Ebinuma H, Miyazaki O, Yago H, Yamauchi T, Horikoshi M, Hara K. Measurement of the high-molecular weight form of adiponectin in plasma is useful for the prediction of insulin resistance and metabolic syndrome. Diabetes Care. 2006 Jun;29 (6):1357-62
  • Hawkins M, Scherer PE, Weaver C, Kwon E, Pajvani UB, Kishore P, Li W, Tonelli J. Mechanisms of early insulin-sensitizing effects of thiazolidinediones in type 2 diabetes. Diabetes. 2004 Jun;53 (6):1621-9
  • Ram A, Yissachar E, Hemi R, Modan-Moses D, Pariente C, Kanety H, Stein D, Yaroslavsky A, Faigin M, Loewenthal R. Modulation of adiponectin and leptin during refeeding of female anorexia nervosa patients. J Clin Endocrinol Metab. 2007 May;92 (5):1843-7
  • Whitehead JP, Mowry BJ, Richards AA, Newell F, Jones AL, Wang AY, Hickman IJ, Prins JB, Macdonald GA. Olanzapine treatment is associated with reduced high molecular weight adiponectin in serum: a potential mechanism for olanzapine-induced insulin resistance in patients with schizophrenia. J Clin Psychopharmacol. 2006 Jun;26 (3):232-7
  • O'Rahilly S, Halberg NH, Burling K, Soos MA, Schraw T, Luan J, Cochran EK, Dunger DB, Wareham NJ, Scherer PE, Gorden P, Semple RK. Paradoxical elevation of high-molecular weight adiponectin in acquired extreme insulin resistance due to insulin receptor antibodies. Diabetes. 2007 Jun;56 (6):1712-7
  • Owens RJ, Kern PA, Ono F, Rasouli N, Banga A, Bodles AM. Pioglitazone increases secretion of high-molecular-weight adiponectin from adipocytes. Am J Physiol Endocrinol Metab. 2006 Nov;291 (5):E1100-5
  • Schraw T, Wang ZV, Halberg N, Hawkins M, Scherer PE. Plasma adiponectin complexes have distinct biochemical characteristics. Endocrinology. 2008 May;149 (5):2270-82
  • Scherer PE, Hawkins M, Halberg N, Wang ZV, Schraw T. Plasma adiponectin complexes have distinct biochemical characteristics. Endocrinology. 2008 May;149 (5):2270-82
  • Xu A, Lam KS, Chan L, Chan KW, Lam JB, Lam MC, Hoo RC, Mak WW, Cooper GJ, Wang Y. Post-translational modifications of the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high molecular weight oligomeric complex. J Biol Chem. 2006 Jun 16;281 (24):16391-400
  • Luley C, Westphal S. Preferential increase in high-molecular weight adiponectin after niacin. Atherosclerosis. 2008 May;198 (1):179-83
  • Shirasawa T, Sano H, Miyashita Y, Matsudaira T, Morimoto A, Nishimura R, Tajima N, Takahashi E. Ratio of high-, medium-, and low-molecular weight serum adiponectin to the total adiponectin value in children. J Pediatr. 2007 Nov;151 (5):545-7, 547.e1-2
  • Matsuda M, Shimomura I, et al. Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis. J Biol Chem. 2002;277:37487-37491.
  • Scherer PE, Rizza RA, Pajvani UB, Basu R. Selective downregulation of the high molecular weight form of adiponectin in hyperinsulinemia and in type 2 diabetes: differential regulation from nondiabetic subjects. Diabetes. 2007 Aug;56 (8):2174-7
  • Taketani Y, Osuga Y, Koga K, Tajima T, Hirota Y, Hirata T, Morimoto C, Harada M, Yano T, Takemura Y. Selective increase in high molecular weight adiponectin concentration in serum of women with preeclampsia. J Reprod Immunol. 2007 Feb;73 (1):60-5
  • Kobayashi H, Ouchi N, Kihara S, Walsh K, Kumada M, Abe Y, Funahashi T, Matsuzawa Y, Ferre P. Selective Suppression of Endothelial Cell Apoptosis by the High Molecular Weight.
  • Kobayashi H, Ouchi N, Kihara S, Walsh K, Kumada M, Abe Y, et al. Selective suppression of endothelial cell apoptosis by the high molecular weight form of adiponectin. Circulation research. 2004 Mar 5;94(4):e27-31.
  • Matsuzawa Y, Funahashi T, Abe Y, Kumada M, Walsh K, Kihara S, Ouchi N, Kobayashi H. Selective suppression of endothelial cell apoptosis by the high molecular weight form of adiponectin. Circ Res. 2004 Mar 5;94 (4):e27-31
  • Lau GK, Zhang HY, Lee NP, Chan W, Yueng YH, Leung KW, Lu L, Leung N, Lo CM, Fan ST, Luk JM, Xu A, Lam KS, Kwong YL, Hui CK. Serum adiponectin is increased in advancing liver fibrosis and declines with reduction in fibrosis in chronic hepatitis B. J Hepatol. 2007 Aug;47 (2):191-202
  • Fisher FF, Trujillo ME, Hanif W, Barnett AH, McTernan PG, Scherer PE, Kumar S. Serum high molecular weight complex of adiponectin correlates better with glucose tolerance than total serum adiponectin in Indo-Asian males. Diabetologia. 2005 Jun;48 (6):1084-7
  • Itoh H, Saito I, Yamamoto Y, Hirose H, Nakatani H. Significance of leptin and high-molecular weight adiponectin in the general population of Japanese male adolescents. Metabolism. 2008 Feb;57 (2):157-62
  • Pajvani UB, Du X, Combs TP, Berg AH, Rajala MW, Schulthess T, Engel J, Brownlee M, Scherer PE. Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity. J Biol Chem. 2003; 278:9073-85.
  • Pajvani UB, Du X, Combs TP, Berg AH, Rajala MW, Schulthess T, Engel J, Brownlee M, Scherer PE. Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity. J Biol Chem. 2003; 278:9073-85.
  • Lodish HF, Tsao TS, Bogan JS, Ahmad NS, Wang J, Hug C. T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin. Proc Natl Acad Sci U S A. 2004 Jul 13;101 (28):10308-13
  • Lam KS, Chan KW, Hoo RL, Wang Y, Tan KC, Zhang J, Chen B, Lam MC, Tse C, Cooper GJ, Xu A. Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes. J Biol Chem. 2005 May 6;280 (18):18073-80
  • Berg AH, Combs TP, Du X, Brownlee M, Scherer PE. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med. 2001; 7:947-953.
  • Hendriks HF, Helander A, Spranger J, Bobbert T, Pelsers M, Kok FJ, van Loon LJ, Beulens JW. The effect of moderate alcohol consumption on adiponectin oligomers and muscle oxidative capacity: a human intervention study. Diabetologia. 2007 Jul;50 (7):1388-92
  • Xu A, Wang Y, Keshaw H, Xu LY, Lam KS, Cooper GJ. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J Clin Invest. 2003; 112:91-100.
  • Yamauchi T, Kamon J, et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med. 2001;7:941-946.
  • Shen Y, Campbell LV, Charlesworth JA, Peake PW, Kriketos AD. The metabolism of isoforms of human adiponectin: studies in human subjects and in experimental animals. Eur J Endocrinol. 2005 Sep;153 (3):409-17
  • Lee DH, Suzuki S, Wilson-Kubalek EM, Wert D, Tsao TS. The oligomeric structure of high molecular weight adiponectin. FEBS Lett. 2007 Mar 6;581 (5):809-14
  • Papademetris X, Rothman DL, Petersen KF, Dufour S, Savage DB, Bilz S, Solomon G, Yonemitsu S, Cline GW, Befroy D, Zemany L, Kahn BB, Shulman GI. The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome. Proc Natl Acad Sci U S A. 2007 Jul 31;104 (31):12587-94
  • Hug C, Lodish HF. The role of the adipocyte hormone adiponectin in cardiovascular disease. Curr Opin Pharmacol. 2005 Apr;5 (2):129-34
  • Andersen M, Flyvbjerg A, Hagen C, Hermann AP, Henriksen JE, Andersen KK, Hojlund K, Frystyk J, Glintborg D. Total and high molecular weight (HMW) adiponectin levels and measures of glucose and lipid metabolism following pioglitazone treatment in a randomized placebo-controlled study in polycystic ovary syndrome. Clin Endocrinol (Oxf). 2008 Feb;68 (2):165-74
  • Tsutamoto T, Tanaka T, Sakai H, Ishikawa C, Fujii M, Yamamoto T, Horie M. Total and high molecular weight adiponectin, haemodynamics, and mortality in patients with chronic heart failure. Eur Heart J. 2007 Jul;28 (14):1723-30
  • Retnakaran R, Liu Y, Shaw C, Tungtrongchitr R, Sweeney G, Hanley A. Total and high molecular weight but not trimeric or hexameric forms of adiponectin correlate with markers of the metabolic syndrome and liver injury in Thai subjects. J Clin Endocrinol Metab. 2007 Nov;92 (11):4313-8
  • Kelesidis T, Kratzsch J, Fasshauer M, Kralisch S, Williams CJ, Mantzoros CS, Bluher M, Brennan AM. Total and high-molecular weight adiponectin in relation to metabolic variables at baseline and in response to an exercise treatment program: comparative evaluation of three assays. Diabetes Care. 2007 Feb;30 (2):280-5
  • Loi KW, Kelly JJ, Charlesworth JA, Shen YY, Peake PW. Up-regulation of adiponectin, its isoforms and receptors in end-stage kidney disease. Nephrol Dial Transplant. 2007 Jan;22 (1):171-8

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