Cardiotrophin-1 (2. Cardiotrophin-1 receptor)
Gp130-gp190 heterocomplex formation is essential for CT-1 signaling. Analysis of the subsequent activation events revealed that CT-1 induces and utilizes Jak1-, Jak2-, and Tyk2-associated tyrosine kinases, which are in turn relayed by STAT-3 transcription factor and MAPK (ERK1 and –2) signaling pathways. Cross-linking of iodinated CT-1 to the cell surface led to the identification of a third alpha component in addition to gp130 and gp190, with an apparent molecular mass of 80 kDa. Removal of n-linked carbohydrates from the protein backbone of the alpha component resulted in a protein of 45 kDa. These results provide evidence that the CT-1 receptor is composed of a tripartite complex, a situation similar to the high affinity receptor for ciliary neurotrophic factor Ref .
Related products
1 results found in Proteins.
3 results found in Antibodies.
| Product: | Size: | ||
|---|---|---|---|
Cardiotrophin 1 Human E. coliType: Recombinant |
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| RD172026100 | 0.1 mg | ||
| Product: | Size: | ||
|---|---|---|---|
Cardiotrophin-1 Human, Mouse Monoclonal Antibody, Clone: 1F3
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| RD1820261001F3 | 0.1 mg | ||
Cardiotrophin-1 Human, Mouse Monoclonal Antibody, Clone: 3G6D9
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| RD182026100-01 | 0.1 mg | ||
Cardiotrophin-1 Human, Rabbit Polyclonal Antibody
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| RD181026100 | 0.1 mg | ||
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