Clusterin (25. Clusterin in Cerebrospinal Fluid)

Clusterin is significantly increased in cerebrospinal fluid from Alzheimer patients compared to unaffected controls, supporting that clusterin might be involved in the pathogenesis of Alzheimer‘s di­sease. However, the individual clusterin levels overlap between the two groups, and thus cerebrospinal fluid clusterin measurement is not suitable as a biochemical marker in the diagnosis of Alzheimer‘s disease ^Ref .

A total of 164 cerebrospinal fluid (CSF) samples taken from neurological patients were classed into four groups according to the clinical diagnosis: multiple sclerosis (MScl, n = 44), clinically isolated syndrome of demyelination (CIS, n = 40), other inflammatory neurological disease (OIND, n = 26) and other neurological disease (OND, n = 54). Three differentially expressed proteins in the comparison of MScl vs. OND were identified: chromogranin A, a potential marker for neurodegeneration; and two important factors in complement-mediated inflammatory reaction, clusterin and complement C3 ^Ref .