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Distributed product

8-OHdG Check (Ultrasensitive) Human ELISA (Multispecies specificity)

  • Regulatory status:RUO
  • Type:Competitive ELISA, Immobilized antigen
  • Other names:8-Hydroxy-2'-deoxyguanosine, 2'-Deoxy-7,8-dihydro-8-oxoguanosine
  • Species:Multispecies
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Cat. No. Size Price


RSCN213101R 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Competitive ELISA, Immobilized antigen

Applications

Urine, Tissue extract

Sample Requirements

50 µl/well

Shipping

At ambient temperature. Upon receipt, store the product at the temperature recommended below.

Storage/Expiration

All reagents should be stored at 2–8°C. The kit should not be used beyond 9 months past the manufacturers date stamped on the exterior of the box.

Calibration Curve

Calibration Range

0.125 –10 ng/ml

Summary

Research topic

Oxidative stress, Animal studies

Summary

8-OHdG is a widely used biomarker for the measurement of endogenous oxidative DNA damage.

Product References (6)

References

  • Kasai H, Crain PF, Kuchino Y, Nishimura S, Ootsuyama A, Tanooka H. Formationof 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicalsand evidence for its repair. Carcinogenesis. 1986 Nov;7(11):1849-51. PubMed PMID:3769133. See more on PubMed
  • Evans MD, Cooke MS, Podmore ID, Zheng Q, Herbert KE, Lunec J. Discrepancies inthe measurement of UVC-induced 8-oxo-2'-deoxyguanosine: implications for theanalysis of oxidative DNA damage. Biochem Biophys Res Commun. 1999 Jun7;259(2):374-8. PubMed PMID: 10362517. See more on PubMed
  • Cooke MS, Evans MD, Lunec J. DNA repair: insights from urinary lesionanalysis. Free Radic Res. 2002 Sep;36(9):929-32. Review. PubMed PMID: 12448817. See more on PubMed
  • Matsubasa T, Uchino T, Karashima S, Kondo Y, Maruyama K, Tanimura M, Endo F.Oxidative stress in very low birth weight infants as measured by urinary 8-OHdG. Free Radic Res. 2002 Feb;36(2):189-93. Erratum in: Free Radic Res 2002Aug;36(8):929. PubMed PMID: 11999387. See more on PubMed
  • Shimoike T, Inoguchi T, Umeda F, Nawata H, Kawano K, Ochi H. The meaning ofserum levels of advanced glycosylation end products in diabetic nephropathy.Metabolism. 2000 Aug;49(8):1030-5. PubMed PMID: 10954022. See more on PubMed
  • Fan WY, Ogusu K, Kouda K, Nakamura H, Satoh T, Ochi H, Takeuchi H. Reducedoxidative DNA damage by vegetable juice intake: a controlled trial. J PhysiolAnthropol Appl Human Sci. 2000 Nov;19(6):287-9. PubMed PMID: 11204876. See more on PubMed
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