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Activin A Human Rat Murine E. coli (E.coli-derived)

  • Regulatory status:RUO
  • Type:Recombinant protein
  • Source:E. coli
  • Other names:Inhibin beta-1, FRP, FSH (Follicle-stimulating hormone)-releasing protein
  • Species:Human, Murine, Rat
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Cat. No. Size Price


RBG10052E002 2 µg
RBG10052E010 10 ug
RBG10052E100 100 μg
PubMed Product Details
Technical Data

Type

Recombinant protein

Description

Activin A is a TGF-β family member that exhibits a wide range of biological activities, including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in postmenopausal women have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-β antagonist, follistatin. Activin A binds to the two forms of activin receptor type I (Act RI-A and Act RI-B) and two forms of activin receptor type II (Act RII-A and Act RII-B). Activins are homodimers or heterodimers of different β subunits. They are produced as precursor proteins with an amino terminal propeptide that is cleaved to release the C-terminal bioactive ligand. Human/Murine/Rat Activin A is a 26.0 kDa disulfide-linked homodimer of two βA chains, each containing 116 amino acid residues.

Amino Acid Sequence

GLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS

Source

E. coli

Purity

97

Biological Activity

The ED50 as determined by its ability to inhibit the proliferation of murine MPC-11 cells is 2.0 ng/ml, corresponding to a specific activity of 5×10 5 units/mg.

Storage/Expiration

 –20°C

Summary

Research topic

Apoptosis, Cardiovascular disease, Neural tissue markers, Oncology

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