Activin B is a TGF-β family member that exhibits a wide range of biological activities, including regulation of embryogenesis, osteogenesis, hematopoiesis, reproductive physiology and hormone secretion from the hypothalamic, pituitary and gonadal glands. Activin B, like certain other members of the TGF-β family, signals through the ActRII receptor (Activin Receptor type II). Activins are homodimers or heterodimers of different β subunits. They are produced as precursor proteins with an amino terminal propeptide that is cleaved to release the C-terminal bioactive ligand. Human Activin B is a 25.6 kDa disulfide-linked homodimer consisting of two βB chains, each containing 115 amino acid residues.
Amino Acid Sequence
(BTI-Tn-5B1-4) Hi-5 Insect cells*
The ED50 as determined by its ability to inhibit the proliferation of murine MPC-11 cells is 2.0 ng/ml, corresponding to a specific activity of 5×105 units/mg.
Endotoxin level is <0.1 ng/μg of protein (<1EU/μg).