United States set
language
Menu Shopping cart $0 Search
Manufactured by BioVendor

Adiponectin Human ELISA, High Sensitivity (Sandwich)

  • Regulatory status:RUO
  • Type:Sandwich ELISA, HRP-labelled antibody
  • Other names:Adipocyte C1q and collagen domain-containing protein, Adipocyte complement-related 30 kDa protein, ACRP30, Adipose most abundant gene transcript 1 protein, apM-1, Gelatin-binding protein, ADIPOQ, ACDC, APM1, GBP28
  • Species:Human
Cat. No. Size Price


RD191023100 96 wells (1 kit) $590
PubMed Product Details
Technical Data

Type

Sandwich ELISA, HRP-labelled antibody

Applications

Serum, Urine, Cerebrospinal fluid, Milk, Plasma

Sample Requirements

10 µl/well

Shipping

At ambient temperature. Upon receipt, store the product at the temperature recommended below.

Storage/Expiration

Store the kit at 2–8°C. Under these conditions, assay components are stable till the expiry date is over. (See the expiry date indicated on the kit label).

Calibration Curve

Limit of Detection

serum or plasma samples: 0.47 ng/ml
milk, CSF or urine: 0.156 ng/ml

Intra-assay (Within-Run)

n=8 CV = 3.9%

Inter-assay (Run-to-Run)

n=8 CV = 6.0%

Spiking Recovery

90.5%

Crossreactivity

  • bovine Non-detectable
  • cat Yes (recommended dilution 1:60)
  • goat Non-detectable
  • horse Non-detectable
  • dog Yes (recommended dilution 1:120)
  • hamster Yes (recommended dilution 1:120)
  • pig Non-detectable
  • rabbit Non-detectable
  • sheep Non-detectable
  • chicken Not tested
  • human Yes
  • rat Yes (recommended dilution 1:60)
  • monkey Yes (recommended dilution 1:600)
  • mouse None-specific binding

Note

The kits are CE-IVD certified and intended for professional use.

Summary

Features

  • European Union: for in vitro diagnostic use
  • Rest of the world: for research use only!
  • The total assay time is less than 3 hours
  • The kit measures total adiponectin in serum, plasma (EDTA, citrate, heparin), urine, cerebrospinal fluid (CSF), and breast milk
  • Assay format is 96 wells
  • Quality Controls are human serum based. No animal sera are used
  • Standards are recombinant adiponectin based
  • Components of the kit are provided ready to use or concentrated

Research topic

Chronic renal failure, Coronary artery disease, Diabetology - Other Relevant Products, Energy metabolism and body weight regulation

Summary

Adiponectin, also referred to as Acrp30, AdipoQ and GBP-28, is a recently discovered 244 aminoacid protein, the product of the apM1 gene, which is physiologically active and specifically and highly expressed in adipose cells. The protein belongs to the soluble defence collagen superfamily; it has a collagen-like domain structurally homologous with collagen VIII and X and complement factor C1q-like globular domain. Adiponectin forms homotrimers, which are the building blocks for higher order complexes found circulating in serum. Together, these complexes make up approximately 0.01% of total serum protein. Adiponectin receptors AdipoR1 and AdipoR2 have been recently cloned; AdipoR1 is abundantly expressed in skeletal muscle, whereas AdipoR2 is predominantly expressed in the liver. Paradoxically, adipose tissue-expressed adiponectin levels are inversely related to the degree of adiposity. Adiponectin concentrations correlate negatively with glucose, insulin, triglyceride concentrations, liver fat content and body mass index and positively with high-density lipoprotein-cholesterol levels, hepatic insulin sensitivity and insulin-stimulated glucose disposal. Adiponectin has been shown to increase insulin sensitivity and decrease plasma glucose by increasing tissue fat oxidation. Of particular interest is that low adiponectin serum levels predict type 2 diabetes independent of other risk factors. Adiponectin also inhibits the inflammatory processes of atherosclerosis suppressing the expression of adhesion and cytokine molecules in vascular endothelial cells and macrophages, respectively. This adipokine plays a role as a scaffold of newly formed collagen in myocardial remodelling after ischaemic injury and also stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signalling in endothelial cells. Low serum adiponectin levels are found in patients with coronary artery disease. Moreover, high circulating levels of adiponectin are associated with decreased risk of myocardial infarction, independent of other factors. Altogether, adiponectin has the potential to become a clinically relevant parameter to be measured routinely in subjects at risk for type 2 diabetes, atherosclerosis and the metabolic syndrome.

Product References (98)

References

  • Blees NR, Wolfswinkel J, Kooistra HS, Corbee RJ. Influence of macronutrient composition of commercial diets on circulating leptin and adiponectin concentrations in overweight dogs. J Anim Physiol Anim Nutr (Berl). 2020 Mar;104(2):698-706. doi: 10.1111/jpn.13285. Epub 2019 Dec 26. PubMed PMID: 31880032. PubMed CentralPMCID: PMC7078794. See more on PubMed
  • Paduszyńska A, Sakowicz A, Banach M, Maciejewski M, Dąbrowa M, Bielecka-Dąbrowa A. Cardioprotective properties of leptin in patients with excessive body mass. Ir J Med Sci. 2020 Nov;189(4):1259-1265. doi: 10.1007/s11845-020-02211-9. Epub 2020 Mar 20. PubMed PMID: 32198598. PubMed CentralPMCID: PMC7554003. See more on PubMed
  • Schön M, Kovaničová Z, Košutzká Z, Nemec M, Tomková M, Jacková L, Máderová D, Slobodová L, Valkovič P, Ukropec J, Ukropcová B. Effects of running on adiponectin, insulin and cytokines in cerebrospinal fluid in healthy young individuals. Sci Rep. 2019 Feb 13;9(1):1959. doi: 10.1038/s41598-018-38201-2. PubMed PMID: 30760755. PubMed CentralPMCID: PMC6374465. See more on PubMed
  • Bielawski K, Rhone P, Bulsa M, Ruszkowska-Ciastek B. Pre-Operative Combination of Normal BMI with Elevated YKL-40 and Leptin but Lower Adiponectin Level Is Linked to a Higher Risk of Breast Cancer Relapse: A Report of Four-Year Follow-Up Study. J Clin Med. 2020 Jun 4;9(6):1742. doi: 10.3390/jcm9061742. PubMed PMID: 32512860. PubMed CentralPMCID: PMC7355849. See more on PubMed
  • Kir S, Ekiz K, Alacam H, Turkel R, Koroglu E, Altintop BL. THE ASSOCIATION BETWEEN PRO AND ANTI-INFLAMMATORY MARKERS WITH THE COMPONENTS OF METABOLIC SYNDROME. Acta Endocrinol (Buchar). 2019 Oct-Dec;15(4):430-435. doi: 10.4183/aeb.2019.430. PubMed PMID: 32377238. PubMed CentralPMCID: PMC7200101. See more on PubMed
  • Ott R, Stupin JH, Melchior K, Schellong K, Ziska T, Dudenhausen JW, Henrich W, Rancourt RC, Plagemann A. Alterations of adiponectin gene expression and DNA methylation in adipose tissues and blood cells are associated with gestational diabetes and neonatal outcome. Clin Epigenetics. 2018 Oct 24;10(1):131. doi: 10.1186/s13148-018-0567-z. PubMed PMID: 30355290. PubMed CentralPMCID: PMC6201547. See more on PubMed
  • Saeidi A, Jabbour G, Ahmadian M, Abbassi-Daloii A, Malekian F, Hackney AC, Saedmocheshi S, Basati G, Ben Abderrahman A, Zouhal H. Independent and Combined Effects of Antioxidant Supplementation and Circuit Resistance Training on Selected Adipokines in Postmenopausal Women. Front Physiol. 2019 Apr 26;10:484. doi: 10.3389/fphys.2019.00484. eCollection 2019. PubMed PMID: 31105587. PubMed CentralPMCID: PMC6499001. See more on PubMed
  • Soyuduru G, Ösoy Adışen E, Kadıoğlu Özer İ, Aksakal AB. The effect of isotretinoin on insulin resistance and adipocytokine levels in acne vulgaris patients. Turk J Med Sci. 2019 Feb 11;49(1):238-244. doi: 10.3906/sag-1806-44. PubMed PMID: 30761880. PubMed CentralPMCID: PMC7350794. See more on PubMed
  • Izaguirre M, Gómez-Ambrosi J, Rodríguez A, Ramírez B, Becerril S, Valentí V, Moncada R, Unamuno X, Silva C, de la Higuera M, Salvador J, Monreal I, Frühbeck G, Catalán V. GLP-1 Limits Adipocyte Inflammation and Its Low Circulating Pre-Operative Concentrations Predict Worse Type 2 Diabetes Remission after Bariatric Surgery in Obese Patients. J Clin Med. 2019 Apr 9;8(4):479. doi: 10.3390/jcm8040479. PubMed PMID: 30970605. PubMed CentralPMCID: PMC6518381. See more on PubMed
  • Mierzyński R, Dłuski D, Nowakowski Ł, Poniedziałek-Czajkowska E, Leszczyńska-Gorzelak B. Adiponectin and Omentin Levels as Predictive Biomarkers of Preterm Birth in Patients with Gestational Diabetes Mellitus. Biomed Res Int. 2018 Sep 18;2018:7154216. doi: 10.1155/2018/7154216. eCollection 2018. PubMed PMID: 30320137. PubMed CentralPMCID: PMC6167585. See more on PubMed
  • Gridneva Z, Kugananthan S, Rea A, Lai CT, Ward LC, Murray K, Hartmann PE, Geddes DT. Human Milk Adiponectin and Leptin and Infant Body Composition over the First 12 Months of Lactation. Nutrients. 2018 Aug 20;10(8):1125. doi: 10.3390/nu10081125. PubMed PMID: 30127292. PubMed CentralPMCID: PMC6115716. See more on PubMed
  • Wiecek M, Szymura J, Maciejczyk M, Kantorowicz M, Szygula Z. Acute Anaerobic Exercise Affects the Secretion of Asprosin, Irisin, and Other Cytokines - A Comparison Between Sexes. Front Physiol. 2018 Dec 10;9:1782. doi: 10.3389/fphys.2018.01782. eCollection 2018. PubMed PMID: 30618797. PubMed CentralPMCID: PMC6295572. See more on PubMed
  • Horakova D, Stepanek L, Nagelova R, Pastucha D, Azeem K, Kollarova H. Total and high-molecular-weight adiponectin levels and prediction of insulin resistance. Endokrynol Pol. 2018;69(4):375-380. doi: 10.5603/EP.a2018.0035. Epub 2018 Jun 28. PubMed PMID: 29952412. See more on PubMed
  • Larsson MW, Lind MV, Larnkjær A, Due AP, Blom IC, Wells J, Lai CT, Mølgaard C, Geddes DT, Michaelsen KF. Excessive Weight Gain Followed by Catch-Down in Exclusively Breastfed Infants: An Exploratory Study. Nutrients. 2018 Sep 12;10(9):1290. doi: 10.3390/nu10091290. PubMed PMID: 30213080. PubMed CentralPMCID: PMC6164044. See more on PubMed
  • Hellmuth C, Uhl O, Demmelmair H, Grunewald M, Auricchio R, Castillejo G, Korponay-Szabo IR, Polanco I, Roca M, Vriezinga SL, Werkstetter KJ, Koletzko B, Mearin ML, Kirchberg FF. The impact of human breast milk components on the infant metabolism. PLoS One. 2018 Jun 1;13(6):e0197713. doi: 10.1371/journal.pone.0197713. eCollection 2018. PubMed PMID: 29856767. PubMed CentralPMCID: PMC5983411. See more on PubMed
  • Wilson R, Willis J, Gearry RB, Hughes A, Lawley B, Skidmore P, Frampton C, Fleming E, Anderson A, Jones L, Tannock GW, Carr AC. SunGold Kiwifruit Supplementation of Individuals with Prediabetes Alters Gut Microbiota and Improves Vitamin C Status, Anthropometric and Clinical Markers. Nutrients. 2018 Jul 12;10(7):895. doi: 10.3390/nu10070895. PubMed PMID: 30002355. PubMed CentralPMCID: PMC6073280. See more on PubMed
  • Escoté X, Félix-Soriano E, Gayoso L, Huerta AE, Alvarado MA, Ansorena D, Astiasarán I, Martínez JA, Moreno-Aliaga MJ. Effects of EPA and lipoic acid supplementation on circulating FGF21 and the fatty acid profile in overweight/obese women following a hypocaloric diet. Food Funct. 2018 May 23;9(5):3028-3036. doi: 10.1039/c8fo00355f. PubMed PMID: 29766165. See more on PubMed
  • Kojima R, Ukawa S, Zhao W, Suzuki K, Yamada H, Tsushita K, Kawamura T, Okabayashi S, Wakai K, Noma H, Ando M, Tamakoshi A. Association of Adiponectin With Cancer and All-Cause Mortality in a Japanese Community-Dwelling Elderly Cohort: A Case-Cohort Study. J Epidemiol. 2018 Aug 5;28(8):367-372. doi: 10.2188/jea.JE20170087. Epub 2018 Mar 24. PubMed PMID: 29576602. PubMed CentralPMCID: PMC6048298. See more on PubMed
  • Szewczyk-Golec K, Rajewski P, Gackowski M, Mila-Kierzenkowska C, Wesołowski R, Sutkowy P, Pawłowska M, Woźniak A. Melatonin Supplementation Lowers Oxidative Stress and Regulates Adipokines in Obese Patients on a Calorie-Restricted Diet. Oxid Med Cell Longev. 2017;2017:8494107. doi: 10.1155/2017/8494107. Epub 2017 Sep 21. PubMed PMID: 29142618. PubMed CentralPMCID: PMC5632922. See more on PubMed
  • Wilson R, Willis J, Gearry R, Skidmore P, Fleming E, Frampton C, Carr A. Inadequate Vitamin C Status in Prediabetes and Type 2 Diabetes Mellitus: Associations with Glycaemic Control, Obesity, and Smoking. Nutrients. 2017 Sep 9;9(9):997. doi: 10.3390/nu9090997. PubMed PMID: 28891932. PubMed CentralPMCID: PMC5622757. See more on PubMed
  • Bahijri SM, Ajabnoor G, Hegazy GA, Alsheikh L, Moumena MZ, Bashanfar BM, Alzahrani AH. Supplementation with Oligonol, Prevents Weight Gain and Improves Lipid Profile in Overweight and Obese Saudi Females. Curr Nutr Food Sci. 2018 Apr;14(2):164-170. doi: 10.2174/1573401313666170609101408. PubMed PMID: 29853817. PubMed CentralPMCID: PMC5907059. See more on PubMed
  • Ahn SY, Kim DK, Han SS, Park JH, Shin SJ, Lee SH, Choi BS, Lim CS, Kim S, Chin HJ. Weight loss has an additive effect on the proteinuria reduction of angiotensin II receptor blockers in hypertensive patients with chronic kidney disease. Kidney Res Clin Pract. 2018 Mar;37(1):49-58. doi: 10.23876/j.krcp.2018.37.1.49. Epub 2018 Mar 31. PubMed PMID: 29629277. PubMed CentralPMCID: PMC5875576. See more on PubMed
  • Kim SJ, Yoon SH, Choi SM, Lee J, Lee CH, Han SK, Yim JJ. Characteristics associated with progression in patients with of nontuberculous mycobacterial lung disease : a prospective cohort study. BMC Pulm Med. 2017 Jan 5;17(1):5. doi: 10.1186/s12890-016-0349-3. PubMed PMID: 28056937. PubMed CentralPMCID: PMC5216528. See more on PubMed
  • Boura P, Grapsa D, Loukides S, Angelidou M, Tsakanika K, Syrigos N, Gkiozos I. The prognostic value of serum and bronchoalveolar lavage levels of adiponectin in advanced non-small-cell lung cancer. Lung Cancer Manag. 2017 Nov;6(2):55-65. doi: 10.2217/lmt-2016-0018. Epub 2017 Nov 17. PubMed PMID: 30643571. PubMed CentralPMCID: PMC6310335. See more on PubMed
  • Zapata RC, Meachem MD, Cardoso NC, Mehain SO, McMillan CJ, Snead ER, Chelikani PK. Differential circulating concentrations of adipokines, glucagon and adropin in a clinical population of lean, overweight and diabetic cats. BMC Vet Res. 2017 Apr 4;13(1):85. doi: 10.1186/s12917-017-1011-x. PubMed PMID: 28376869. PubMed CentralPMCID: PMC5379571. See more on PubMed
  • Leclerc L, Thorin C, Flanagan J, Biourge V, Serisier S, Nguyen P. Higher neonatal growth rate and body condition score at 7 months are predictive factors of obesity in adult female Beagle dogs. BMC Vet Res. 2017 Apr 13;13(1):104. doi: 10.1186/s12917-017-0994-7. PubMed PMID: 28407742. PubMed CentralPMCID: PMC5390368. See more on PubMed
  • Ajabnoor GM, Bahijri S, Shaik NA, Borai A, Alamoudi AA, Al-Aama JY, Chrousos GP. Ramadan fasting in Saudi Arabia is associated with altered expression of CLOCK, DUSP and IL-1alpha genes, as well as changes in cardiometabolic risk factors. PLoS One. 2017 Apr 6;12(4):e0174342. doi: 10.1371/journal.pone.0174342. eCollection 2017. PubMed PMID: 28384165. PubMed CentralPMCID: PMC5401765. See more on PubMed
  • Mazloomi S, Alizadeh N, Aminzare M, Niroomand S, Mousavi SN. RETRACTED ARTICLE: Serum Zinc and Adiponectin Levels in Patients with Polycystic Ovary Syndrome, Adjusted for Anthropometric, Biochemical, Dietary Intake, and Physical Activity Measures. Biol Trace Elem Res. 2018 Feb;181(2):388. doi: 10.1007/s12011-017-0951-0. Epub 2017 Feb 3. PubMed PMID: 28160242. See more on PubMed
  • Tvarijonaviciute A, Cerón JJ, Tecles F. Serum adiponectin concentration in dogs - absence of diurnal variation and lack of effect of feeding and methylprednisolone administration. Acta Vet Hung. 2012 Dec;60(4):489-500. doi: 10.1556/AVet.2012.043. PubMed PMID: 23160031. See more on PubMed
  • Wójcik K, Jabłonowska E, Omulecka A, Piekarska A. Insulin resistance, adipokine profile and hepatic expression of SOCS-3 gene in chronic hepatitis C. World J Gastroenterol. 2014 Aug 14;20(30):10449-56. doi: 10.3748/wjg.v20.i30.10449. PubMed PMID: 25132761. PubMed CentralPMCID: PMC4130852. See more on PubMed
  • Bužga M, Evžen M, Pavel K, Tomáš K, Vladislava Z, Pavel Z, Svagera Z. Effects of the intragastric balloon MedSil on weight loss, fat tissue, lipid metabolism, and hormones involved in energy balance. Obes Surg. 2014 Jun;24(6):909-15. doi: 10.1007/s11695-014-1191-4. PubMed PMID: 24488758. PubMed CentralPMCID: PMC4022986. See more on PubMed
  • Waluga M, Hartleb M, Boryczka G, Kukla M, Zwirska-Korczala K. Serum adipokines in inflammatory bowel disease. World J Gastroenterol. 2014 Jun 14;20(22):6912-7. doi: 10.3748/wjg.v20.i22.6912. PubMed PMID: 24944482. PubMed CentralPMCID: PMC4051931. See more on PubMed
  • Bjornvad CR, Rand JS, Tan HY, Jensen KS, Rose FJ, Armstrong PJ, Whitehead JP. Obesity and sex influence insulin resistance and total and multimer adiponectin levels in adult neutered domestic shorthair client-owned cats. Domest Anim Endocrinol. 2014 Apr;47:55-64. doi: 10.1016/j.domaniend.2013.11.006. Epub 2013 Dec 5. PubMed PMID: 24373250. See more on PubMed
  • Sahebkar A, Watts GF. Fibrate therapy and circulating adiponectin concentrations: a systematic review and meta-analysis of randomized placebo-controlled trials. Atherosclerosis. 2013 Sep;230(1):110-20. doi: 10.1016/j.atherosclerosis.2013.06.026. Epub 2013 Jul 12. PubMed PMID: 23958262. See more on PubMed
  • Luque-Ramírez M, Martínez-García MÁ, Montes-Nieto R, Fernández-Durán E, Insenser M, Alpañés M, Escobar-Morreale HF. Sexual dimorphism in adipose tissue function as evidenced by circulating adipokine concentrations in the fasting state and after an oral glucose challenge. Hum Reprod. 2013 Jul;28(7):1908-18. doi: 10.1093/humrep/det097. Epub 2013 Apr 4. PubMed PMID: 23559188. See more on PubMed
  • Teijeira-Fernandez E, Eiras S, Salgado Somoza A, Gonzalez-Juanatey JR. Baseline epicardial adipose tissue adiponectin levels predict cardiovascular outcomes: a long-term follow-up study. Cytokine. 2012 Dec;60(3):674-80. doi: 10.1016/j.cyto.2012.08.012. Epub 2012 Sep 11. PubMed PMID: 22974530. See more on PubMed
  • Oranskiy SP, Yeliseyeva LN, Tsanaeva AV, Zaytseva NV. Body composition and serum levels of adiponectin, vascular endothelial growth factor, and interleukin-6 in patients with rheumatoid arthritis. Croat Med J. 2012 Aug;53(4):350-6. doi: 10.3325/cmj.2012.53.350. PubMed PMID: 22911528. PubMed CentralPMCID: PMC3429942. See more on PubMed
  • Ortega-Senovilla H, Schaefer-Graf U, Meitzner K, Abou-Dakn M, Graf K, Kintscher U, Herrera E. Gestational diabetes mellitus causes changes in the concentrations of adipocyte fatty acid-binding protein and other adipocytokines in cord blood. Diabetes Care. 2011 Sep;34(9):2061-6. doi: 10.2337/dc11-0715. Epub 2011 Jul 20. PubMed PMID: 21775757. PubMed CentralPMCID: PMC3161255. See more on PubMed
  • Hulejová H, Levitová A, Kuklová M, Stochl J, Haluzík M, Pavelka K, Vencovský J, Senolt L. No effect of physiotherapy on the serum levels of adipocytokines in patients with ankylosing spondylitis. Clin Rheumatol. 2012 Jan;31(1):67-71. doi: 10.1007/s10067-011-1773-7. Epub 2011 May 28. PubMed PMID: 21618078. See more on PubMed
  • Catalán V, Gómez-Ambrosi J, Rodríguez A, Silva C, Rotellar F, Gil MJ, Cienfuegos JA, Salvador J, Frühbeck G. Expression of caveolin-1 in human adipose tissue is upregulated in obesity and obesity-associated type 2 diabetes mellitus and related to inflammation. Clin Endocrinol (Oxf). 2008 Feb;68(2):213-9. doi: 10.1111/j.1365-2265.2007.03021.x. Epub 2007 Sep 4. PubMed PMID: 17803693. See more on PubMed
  • Asgeirsson T, Zhang S, Khoo SK, Resau JH, Dujovny N, Senagore AJ. Serum adiponectin, resistin, and circulating soluble receptor for advanced glycation end products in colectomy patients. Mediators Inflamm. 2011;2011:916807. doi: 10.1155/2011/916807. Epub 2011 Sep 7. PubMed PMID: 21912448. PubMed CentralPMCID: PMC3168899. See more on PubMed
  • Šenolt L, Kuklová M, Cerezo LA, Hulejová H, Filková M, Bošanská L, Pecha O, Pavelka K, Haluzík M, Vencovský J. Adipokine profile is modulated in subcutaneous adipose tissue by TNFα inhibitors in patients with rheumatoid arthritis. Ann Rheum Dis. 2011 Nov;70(11):2054-6. doi: 10.1136/ard.2011.152603. Epub 2011 May 27. PubMed PMID: 21622768. See more on PubMed
  • Tvarijonaviciute A, Eralp O, Kocaturk M, Yilmaz Z, Ceron JJ. Adiponectin and IGF-1 are negative acute phase proteins in a dog model of acute endotoxaemia. Vet Immunol Immunopathol. 2011 Mar 15;140(1-2):147-51. doi: 10.1016/j.vetimm.2010.11.011. Epub 2010 Nov 18. PubMed PMID: 21145113. See more on PubMed
  • Bronsky J, Mitrova K, Karpisek M, Mazoch J, Durilova M, Fisarkova B, Stechova K, Prusa R, Nevoral J. Adiponectin, AFABP, and leptin in human breast milk during 12 months of lactation. J Pediatr Gastroenterol Nutr. 2011 Apr;52(4):474-7. doi: 10.1097/MPG.0b013e3182062fcc. PubMed PMID: 21407103. See more on PubMed
  • Tvarijonaviciute A, Martínez-Subiela S, Ceron JJ. Validation of 2 commercially available enzyme-linked immunosorbent assays for adiponectin determination in canine serum samples. Can J Vet Res. 2010 Oct;74(4):279-85. PubMed PMID: 21197228. PubMed CentralPMCID: PMC2949341. See more on PubMed
  • Tsai JP, Liou HH, Liu HM, Lee CJ, Lee RP, Hsu BG. Fasting serum fatty acid-binding protein 4 level positively correlates with metabolic syndrome in hemodialysis patients. Arch Med Res. 2010 Oct;41(7):536-40. doi: 10.1016/j.arcmed.2010.09.007. PubMed PMID: 21167393. See more on PubMed
  • Tvarijonaviciute A, Tecles F, Ceron JJ. Relationship between serum butyrylcholinesterase and obesity in dogs: a preliminary report. Vet J. 2010 Nov;186(2):197-200. doi: 10.1016/j.tvjl.2009.07.030. Epub 2009 Sep 3. PubMed PMID: 19733105. See more on PubMed
  • Tuttolomondo A, La Placa S, Di Raimondo D, Bellia C, Caruso A, Lo Sasso B, Guercio G, Diana G, Ciaccio M, Licata G, Pinto A. Adiponectin, resistin and IL-6 plasma levels in subjects with diabetic foot and possible correlations with clinical variables and cardiovascular co-morbidity. Cardiovasc Diabetol. 2010 Sep 13;9:50. doi: 10.1186/1475-2840-9-50. PubMed PMID: 20836881. PubMed CentralPMCID: PMC2946274. See more on PubMed
  • Dieplinger B, Gegenhuber A, Kaar G, Poelz W, Haltmayer M, Mueller T. Prognostic value of established and novel biomarkers in patients with shortness of breath attending an emergency department. Clin Biochem. 2010 Jun;43(9):714-9. doi: 10.1016/j.clinbiochem.2010.02.002. Epub 2010 Feb 11. PubMed PMID: 20153308. See more on PubMed
  • Onat A, Can G, Hergenç G, Küçükdurmaz Z, Uğur M, Yüksel H. High absolute coronary disease risk among Turks: involvement of risk factors additional to conventional ones. Cardiology. 2010;115(4):297-306. doi: 10.1159/000312009. Epub 2010 Apr 16. PubMed PMID: 20395681. See more on PubMed
  • Cabré A, Lázaro I, Girona J, Manzanares JM, Marimón F, Plana N, Guardiola M, Heras M, Masana L. The APOA5-1131 T>C variant enhances the association between RBP4 and hypertriglyceridemia in diabetes. Nutr Metab Cardiovasc Dis. 2010 May;20(4):243-8. doi: 10.1016/j.numecd.2009.04.003. Epub 2009 Sep 17. PubMed PMID: 19765959. See more on PubMed
  • Iacobellis G, Petramala L, Cotesta D, Pergolini M, Zinnamosca L, Cianci R, De Toma G, Sciomer S, Letizia C. Adipokines and cardiometabolic profile in primary hyperaldosteronism. J Clin Endocrinol Metab. 2010 May;95(5):2391-8. doi: 10.1210/jc.2009-2204. Epub 2010 Mar 1. PubMed PMID: 20194710. See more on PubMed
  • Hancke K, Grubeck D, Hauser N, Kreienberg R, Weiss JM. Adipocyte fatty acid-binding protein as a novel prognostic factor in obese breast cancer patients. Breast Cancer Res Treat. 2010 Jan;119(2):367-7. doi: 10.1007/s10549-009-0577-9. PubMed PMID: 19842034. See more on PubMed
  • Sáinz N, Rodríguez A, Catalán V, Becerril S, Ramírez B, Gómez-Ambrosi J, Frühbeck G. Leptin administration favors muscle mass accretion by decreasing FoxO3a and increasing PGC-1alpha in ob/ob mice. PLoS One. 2009 Sep 4;4(9):e6808. doi: 10.1371/journal.pone.0006808. PubMed PMID: 19730740. PubMed CentralPMCID: PMC2733298. See more on PubMed
  • Sodi R, Hazell MJ, Durham BH, Rees C, Ranganath LR, Fraser WD. The circulating concentration and ratio of total and high molecular weight adiponectin in post-menopausal women with and without osteoporosis and its association with body mass index and biochemical markers of bone metabolism. Clin Biochem. 2009 Sep;42(13-14):1375-80. doi: 10.1016/j.clinbiochem.2009.06.003. Epub 2009 Jun 10. PubMed PMID: 19523465. See more on PubMed
  • Murdolo G, Hammarstedt A, Schmelz M, Jansson PA, Smith U. Acute hyperinsulinemia differentially regulates interstitial and circulating adiponectin oligomeric pattern in lean and insulin-resistant, obese individuals. J Clin Endocrinol Metab. 2009 Nov;94(11):4508-16. doi: 10.1210/jc.2009-0431. Epub 2009 Oct 9. PubMed PMID: 19820029. See more on PubMed
  • Selva DM, Lecube A, Hernández C, Baena JA, Fort JM, Simó R. Lower zinc-alpha2-glycoprotein production by adipose tissue and liver in obese patients unrelated to insulin resistance. J Clin Endocrinol Metab. 2009 Nov;94(11):4499-507. doi: 10.1210/jc.2009-0758. Epub 2009 Jul 21. PubMed PMID: 19622624. See more on PubMed
  • Haluzíková D, Dostálová I, Kaválková P, Roubíček T, Mráz M, Papežová H, Haluzík M. Serum concentrations of adipocyte fatty acid binding protein in patients with anorexia nervosa. Physiol Res. 2009;58(4):577-581. doi: 10.33549/physiolres.931575. Epub 2008 Jul 25. PubMed PMID: 18657008. See more on PubMed
  • Dieplinger B, Haltmayer M, Poelz W, Mueller T. Value of adiponectin as predictor of 5-year all-cause mortality in patients with symptomatic peripheral arterial disease: results from the Linz Peripheral Arterial Disease (LIPAD) study. Clin Chim Acta. 2009 Oct;408(1-2):87-91. doi: 10.1016/j.cca.2009.07.014. Epub 2009 Jul 30. PubMed PMID: 19646980. See more on PubMed
  • Drechsler C, Krane V, Winkler K, Dekker FW, Wanner C. Changes in adiponectin and the risk of sudden death, stroke, myocardial infarction, and mortality in hemodialysis patients. Kidney Int. 2009 Sep;76(5):567-75. doi: 10.1038/ki.2009.200. Epub 2009 Jun 10. PubMed PMID: 19516245. See more on PubMed
  • von Eynatten M, Liu D, Hock C, Oikonomou D, Baumann M, Allolio B, Korosoglou G, Morcos M, Campean V, Amann K, Lutz J, Heemann U, Nawroth PP, Bierhaus A, Humpert PM. Urinary adiponectin excretion: a novel marker for vascular damage in type 2 diabetes. Diabetes. 2009 Sep;58(9):2093-9. doi: 10.2337/db09-0204. Epub 2009 Jun 9. PubMed PMID: 19509019. PubMed CentralPMCID: PMC2731516. See more on PubMed
  • Dieplinger B, Gegenhuber A, Haltmayer M, Mueller T. Evaluation of novel biomarkers for the diagnosis of acute destabilised heart failure in patients with shortness of breath. Heart. 2009 Sep;95(18):1508-13. doi: 10.1136/hrt.2009.170696. Epub 2009 Jun 11. PubMed PMID: 19525245. See more on PubMed
  • Dieplinger B, Gegenhuber A, Poelz W, Haltmayer M, Mueller T. Prognostic value of increased adiponectin plasma concentrations in patients with acute destabilized heart failure. Clin Biochem. 2009 Jul;42(10-11):1190-3. doi: 10.1016/j.clinbiochem.2009.02.023. Epub 2009 Mar 6. PubMed PMID: 19272369. See more on PubMed
  • Capel F, Klimcáková E, Viguerie N, Roussel B, Vítková M, Kováciková M, Polák J, Kovácová Z, Galitzky J, Maoret JJ, Hanácek J, Pers TH, Bouloumié A, Stich V, Langin D. Macrophages and adipocytes in human obesity: adipose tissue gene expression and insulin sensitivity during calorie restriction and weight stabilization. Diabetes. 2009 Jul;58(7):1558-67. doi: 10.2337/db09-0033. Epub 2009 Apr 28. PubMed PMID: 19401422. PubMed CentralPMCID: PMC2699855. See more on PubMed
  • Onat A, Hergenç G, Can G, Küçükdurmaz Z. Serum adiponectin confers little protection against diabetes and hypertension in Turkish men. Obesity (Silver Spring). 2009 Mar;17(3):564-70. doi: 10.1038/oby.2008.564. Epub 2008 Dec 18. PubMed PMID: 19238142. See more on PubMed
  • Onat A, Hergenç G, Agirbaşli M, Kaya Z, Can G, Unaltuna NE. Preheparin serum lipoprotein lipase mass interacts with gender, gene polymorphism and, positively, with smoking. Clin Chem Lab Med. 2009;47(2):208-15. doi: 10.1515/CCLM.2009.018. PubMed PMID: 19191728. See more on PubMed
  • Stejskal D, Karpisek M, Hanulova Z, Svestak M. Chemerin is an independent marker of the metabolic syndrome in a Caucasian population--a pilot study. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2008 Dec;152(2):217-21. doi: 10.5507/bp.2008.033. PubMed PMID: 19219210. See more on PubMed
  • Filková M, Lisková M, Hulejová H, Haluzík M, Gatterová J, Pavelková A, Pavelka K, Gay S, Müller-Ladner U, Senolt L. Increased serum adiponectin levels in female patients with erosive compared with non-erosive osteoarthritis. Ann Rheum Dis. 2009 Feb;68(2):295-6. doi: 10.1136/ard.2008.095737. PubMed PMID: 19139213. See more on PubMed
  • Karapanagiotou EM, Tsochatzis EA, Dilana KD, Tourkantonis I, Gratsias I, Syrigos KN. The significance of leptin, adiponectin, and resistin serum levels in non-small cell lung cancer (NSCLC). Lung Cancer. 2008 Sep;61(3):391-7. doi: 10.1016/j.lungcan.2008.01.018. Epub 2008 Mar 14. PubMed PMID: 18342391. See more on PubMed
  • Onat A, Hergenç G, Dursunoğlu D, Küçükdurmaz Z, Bulur S, Can G. Relatively high levels of serum adiponectin in obese women, a potential indicator of anti-inflammatory dysfunction: relation to sex hormone-binding globulin. Int J Biol Sci. 2008 Jul 25;4(4):208-14. doi: 10.7150/ijbs.4.208. PubMed PMID: 18695734. PubMed CentralPMCID: PMC2491727. See more on PubMed
  • Serelis J, Kontogianni MD, Katsiougiannis S, Bletsa M, Tektonidou MG, Skopouli FN. Effect of anti-TNF treatment on body composition and serum adiponectin levels of women with rheumatoid arthritis. Clin Rheumatol. 2008 Jun;27(6):795-7. doi: 10.1007/s10067-008-0855-7. Epub 2008 Feb 28. PubMed PMID: 18305977. See more on PubMed
  • Catalán V, Gómez-Ambrosi J, Pastor C, Rotellar F, Silva C, Rodríguez A, Gil MJ, Cienfuegos JA, Salvador J, Vendrell J, Frühbeck G. Influence of morbid obesity and insulin resistance on gene expression levels of AQP7 in visceral adipose tissue and AQP9 in liver. Obes Surg. 2008 Jun;18(6):695-701. doi: 10.1007/s11695-008-9453-7. Epub 2008 Apr 10. PubMed PMID: 18401671. See more on PubMed
  • Marinoni E, Letizia C, Ciardo F, Corona G, Moscarini M, Di Iorio R. Effects of prenatal betamethasone administration on leptin and adiponectin concentrations in maternal and fetal circulation. Am J Obstet Gynecol. 2008 Aug;199(2):141.e1-6. doi: 10.1016/j.ajog.2008.02.047. Epub 2008 May 23. PubMed PMID: 18456235. See more on PubMed
  • Hennige AM, Staiger H, Wicke C, Machicao F, Fritsche A, Häring HU, Stefan N. Fetuin-A induces cytokine expression and suppresses adiponectin production. PLoS One. 2008 Mar 12;3(3):e1765. doi: 10.1371/journal.pone.0001765. PubMed PMID: 18335040. PubMed CentralPMCID: PMC2258416. See more on PubMed
  • Schnabel R, Messow CM, Lubos E, Espinola-Klein C, Rupprecht HJ, Bickel C, Sinning C, Tzikas S, Keller T, Genth-Zotz S, Lackner KJ, Münzel TF, Blankenberg S. Association of adiponectin with adverse outcome in coronary artery disease patients: results from the AtheroGene study. Eur Heart J. 2008 Mar;29(5):649-57. doi: 10.1093/eurheartj/ehn009. Epub 2008 Feb 9. PubMed PMID: 18263867. See more on PubMed
  • Benedict C, Kern W, Schultes B, Born J, Hallschmid M. Differential sensitivity of men and women to anorexigenic and memory-improving effects of intranasal insulin. J Clin Endocrinol Metab. 2008 Apr;93(4):1339-44. doi: 10.1210/jc.2007-2606. Epub 2008 Jan 29. PubMed PMID: 18230654. See more on PubMed
  • Vaverkova H, Karasek D, Novotny D, Jackuliakova D, Halenka M, Lukes J, Frohlich J. Positive association of adiponectin with soluble vascular cell adhesion molecule sVCAM-1 levels in patients with vascular disease or dyslipidemia. Atherosclerosis. 2008 Apr;197(2):725-31. doi: 10.1016/j.atherosclerosis.2007.07.005. Epub 2007 Aug 21. PubMed PMID: 17714716. See more on PubMed
  • Polak J, Kovacova Z, Holst C, Verdich C, Astrup A, Blaak E, Patel K, Oppert JM, Langin D, Martinez JA, Sørensen TI, Stich V. Total adiponectin and adiponectin multimeric complexes in relation to weight loss-induced improvements in insulin sensitivity in obese women: the NUGENOB study. Eur J Endocrinol. 2008 Apr;158(4):533-41. doi: 10.1530/EJE-07-0512. PubMed PMID: 18362301. See more on PubMed
  • Golledge J, Jayalath R, Oliver L, Parr A, Schurgers L, Clancy P. Relationship between CT anthropometric measurements, adipokines and abdominal aortic calcification. Atherosclerosis. 2008 Mar;197(1):428-34. doi: 10.1016/j.atherosclerosis.2007.06.027. Epub 2007 Aug 6. PubMed PMID: 17675038. PubMed CentralPMCID: PMC2288671. See more on PubMed
  • Catalán V, Gómez-Ambrosi J, Ramirez B, Rotellar F, Pastor C, Silva C, Rodríguez A, Gil MJ, Cienfuegos JA, Frühbeck G. Proinflammatory cytokines in obesity: impact of type 2 diabetes mellitus and gastric bypass. Obes Surg. 2007 Nov;17(11):1464-74. doi: 10.1007/s11695-008-9424-z. PubMed PMID: 18219773. See more on PubMed
  • Lamounier-Zepter V, Bornstein SR, Kunes J, Zicha J, Krsek M, Ehrhart-Bornstein M, Ziegler CG, Kiessling A, Funk RH, Haluzik M. Adrenocortical changes and arterial hypertension in lipoatrophic A-ZIP/F-1 mice. Mol Cell Endocrinol. 2008 Jan 2;280(1-2):39-46. doi: 10.1016/j.mce.2007.09.012. Epub 2007 Oct 18. PubMed PMID: 18045774. See more on PubMed
  • Corpeleijn E, Feskens EJ, Jansen EH, Mensink M, Saris WH, Blaak EE. Lifestyle intervention and adipokine levels in subjects at high risk for type 2 diabetes: the Study on Lifestyle intervention and Impaired glucose tolerance Maastricht (SLIM). Diabetes Care. 2007 Dec;30(12):3125-7. doi: 10.2337/dc07-0457. Epub 2007 Sep 21. PubMed PMID: 17890316. See more on PubMed
  • Avignon A, Sultan A, Piot C, Mariano-Goulart D, Thuan Dit Dieudonné JF, Cristol JP, Dupuy AM. Osteoprotegerin: a novel independent marker for silent myocardial ischemia in asymptomatic diabetic patients. Diabetes Care. 2007 Nov;30(11):2934-9. doi: 10.2337/dc07-0992. Epub 2007 Aug 21. PubMed PMID: 17712025. See more on PubMed
  • Duus K, Pagh RT, Holmskov U, Højrup P, Skov S, Houen G. Interaction of calreticulin with CD40 ligand, TRAIL and Fas ligand. Scand J Immunol. 2007 Nov;66(5):501-7. doi: 10.1111/j.1365-3083.2007.01999.x. PubMed PMID: 17953526. See more on PubMed
  • Tsioufis C, Dimitriadis K, Selima M, Thomopoulos C, Mihas C, Skiadas I, Tousoulis D, Stefanadis C, Kallikazaros I. Low-grade inflammation and hypoadiponectinaemia have an additive detrimental effect on aortic stiffness in essential hypertensive patients. Eur Heart J. 2007 May;28(9):1162-9. doi: 10.1093/eurheartj/ehm089. Epub 2007 Apr 19. PubMed PMID: 17446227. See more on PubMed
  • Cabré A, Lázaro I, Girona J, Manzanares J, Marimón F, Plana N, Heras M, Masana L. Retinol-binding protein 4 as a plasma biomarker of renal dysfunction and cardiovascular disease in type 2 diabetes. J Intern Med. 2007 Oct;262(4):496-503. doi: 10.1111/j.1365-2796.2007.01849.x. PubMed PMID: 17875187. See more on PubMed
  • Gómez-Ambrosi J, Catalán V, Ramírez B, Rodríguez A, Colina I, Silva C, Rotellar F, Mugueta C, Gil MJ, Cienfuegos JA, Salvador J, Frühbeck G. Plasma osteopontin levels and expression in adipose tissue are increased in obesity. J Clin Endocrinol Metab. 2007 Sep;92(9):3719-27. doi: 10.1210/jc.2007-0349. Epub 2007 Jun 26. PubMed PMID: 17595250. See more on PubMed
  • Otto C, Otto B, Frost RJ, Vogeser M, Pfeiffer AF, Spranger J, Parhofer KG. Short-term therapy with atorvastatin or fenofibrate does not affect plasma ghrelin, resistin or adiponectin levels in type 2 diabetic patients with mixed hyperlipoproteinaemia. Acta Diabetol. 2007 Jun;44(2):65-8. doi: 10.1007/s00592-007-0244-8. Epub 2007 May 27. PubMed PMID: 17530469. See more on PubMed
  • Stejskal D, Proskova J, Solichova P. Adiponectin added into the plasma of healthy probands does not affect platelet aggregability. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2006 Jul;150(1):89-90. doi: 10.5507/bp.2006.011. PubMed PMID: 16936907. See more on PubMed
  • Risch L, Saely C, Hoefle G, Rein P, Langer P, Gouya G, Marte T, Aczel S, Drexel H. Relationship between glomerular filtration rate and the adipokines adiponectin, resistin and leptin in coronary patients with predominantly normal or mildly impaired renal function. Clin Chim Acta. 2007 Feb;376(1-2):108-13. doi: 10.1016/j.cca.2006.07.026. Epub 2006 Jul 29. PubMed PMID: 16956602. See more on PubMed
  • Baranova A, Gowder SJ, Schlauch K, Elariny H, Collantes R, Afendy A, Ong JP, Goodman Z, Chandhoke V, Younossi ZM. Gene expression of leptin, resistin, and adiponectin in the white adipose tissue of obese patients with non-alcoholic fatty liver disease and insulin resistance. Obes Surg. 2006 Sep;16(9):1118-25. doi: 10.1381/096089206778392149. PubMed PMID: 16989692. See more on PubMed
  • Park E, Shin MJ, Chung N. The associations between serum leptin, adiponectin and intercellular adhesion molecule-1 in hypercholesterolemic patients. Nutr Res Pract. 2007 Spring;1(1):65-9. doi: 10.4162/nrp.2007.1.1.65. Epub 2007 Mar 31. PubMed PMID: 20535388. PubMed CentralPMCID: PMC2882580. See more on PubMed
  • Bobbert T, Wegewitz U, Brechtel L, Freudenberg M, Mai K, Möhlig M, Diederich S, Ristow M, Rochlitz H, Pfeiffer AF, Spranger J. Adiponectin oligomers in human serum during acute and chronic exercise: relation to lipid metabolism and insulin sensitivity. Int J Sports Med. 2007 Jan;28(1):1-8. doi: 10.1055/s-2006-924028. Epub 2006 Nov 28. PubMed PMID: 17133288. See more on PubMed
  • Santaniemi M, Kesäniemi YA, Ukkola O. Low plasma adiponectin concentration is an indicator of the metabolic syndrome. Eur J Endocrinol. 2006 Nov;155(5):745-50. doi: 10.1530/eje.1.02287. PubMed PMID: 17062891. See more on PubMed
  • Risch L, Hoefle G, Saely C, Berchthold S, Weber M, Gouya G, Rein P, Langer P, Marte T, Aczel S, Drexel H. Evaluation of two fully automated novel enzyme-linked immunosorbent assays for the determination of human adiponectin in serum. Clin Chim Acta. 2006 Nov;373(1-2):121-6. doi: 10.1016/j.cca.2006.05.017. Epub 2006 May 17. PubMed PMID: 16797517. See more on PubMed
  • Bronsky J, Karpísek M, Bronská E, Pechová M, Jancíková B, Kotolová H, Stejskal D, Prusa R, Nevoral J. Adiponectin, adipocyte fatty acid binding protein, and epidermal fatty acid binding protein: proteins newly identified in human breast milk. Clin Chem. 2006 Sep;52(9):1763-70. doi: 10.1373/clinchem.2005.063032. Epub 2006 Jul 27. PubMed PMID: 16873294. See more on PubMed
  • Chu MC, Cosper P, Orio F, Carmina E, Lobo RA. Insulin resistance in postmenopausal women with metabolic syndrome and the measurements of adiponectin, leptin, resistin, and ghrelin. Am J Obstet Gynecol. 2006 Jan;194(1):100-4. doi: 10.1016/j.ajog.2005.06.073. PubMed PMID: 16389017. See more on PubMed
  • Efstathiou SP, Tsioulos DI, Tsiakou AG, Gratsias YE, Pefanis AV, Mountokalakis TD. Plasma adiponectin levels and five-year survival after first-ever ischemic stroke. Stroke. 2005 Sep;36(9):1915-9. doi: 10.1161/01.STR.0000177874.29849.f0. Epub 2005 Aug 18. PubMed PMID: 16109902. See more on PubMed
Summary References (17)

References to Adiponectin

  • Lam KS, Xu A. Adiponectin: protection of the endothelium. Curr Diab Rep. 2005, 5, 254–259.
  • Ding X, Saxena NK, Lin S, Xu A, Srinivasan S, Anania FA. The roles of leptin and adiponectin: a novel paradigm in adipocytokine regulation of liver fibrosis and stellate cell biology. Am J Pathol. 2005, 166, 1655–1669.
  • Xu A, Chan KW, Hoo RL, Wang Y, Tan KC, Zhang J, Chen B, Lam MC, Tse C, Cooper GJ, Lam KS. Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes. J Biol Chem. 2005, 280, 18073–18080.
  • Wang Y, Lam KS, Xu JY, Lu G, Xu LY, Cooper GJ, Xu A. Adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization-dependent manner. J Biol Chem. 2005, 280, 18341–18347.
  • Ouchi N, Kobayashi H, Kihara S, Kumada M, Sato K, Inoue T, Funahashi T, Walsh K. Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells. J Biol Chem. 2004, 279, 1304–1309.
  • Ishikawa Y, Akasaka Y, Ishii T, Yoda-Murakami M, Choi-Miura NH, Tomita M, Ito K, Zhang L, Akishima Y, Ishihara M, Muramatsu M, Taniyama M. Changes in the distribution pattern of gelatinbinding protein of 28 kDa (adiponectin) in myocardial remodelling after ischaemic injury. Histopathology. 2003, 42, 43–52.
  • Diez JJ, Iglesias P. The role of the novel adipocyte-derived hormone adiponectin in human disease. Eur J Endocrinol. 2003, 148, 293–300.
  • Waki H, Yamauchi T, Kamon J, Ito Y, Uchida S, Kita S, Hara K, Hada Y, Vasseur F, Froguel P, Kimura S, Nagai R, Kadowaki T. Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin. J Biol Chem. 2003, 278, 40352–40363.
  • Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. 2003, 423, 762–769.
  • Yamauchi T, Kamon J, Waki H, Imai Y, Shimozawa N, Hioki K, Uchida S, Ito Y, Takakuwa K, Matsui J, Takata M, Eto K, Terauchi Y, Komeda K, Tsunoda M, Murakami K, Ohnishi Y, Naitoh T, Yamamura K, Ueyama Y, Froguel P, Kimura S, Nagai R, Kadowaki T. Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis. J Biol Chem. 2003, 278, 2461–2468.
  • Daimon M, Oizumi T, Saitoh T, Kameda W, Hirata A, Yamaguchi H, Ohnuma H, Igarashi M, Tominaga M, Kato T. Decreased serum levels of adiponectin are a risk factor for the progression to type 2 diabetes in the Japanese Population: the Funagata study. Diabetes Care. 2003 Jul;26(7):2015–20.
  • Pajvani UB, Du X, Combs TP, Berg AH, Rajala MW, Schulthess T, Engel J, Brownlee M, Scherer PE. Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications for metabolic regulation and bioactivity. J Biol Chem. 2003, 278, 9073–9085.
  • Spranger J, Kroke A, Mohlig M, Bergmann MM, Ristow M, Boeing H, Pfeiffer AF. Adiponectin and protection against type 2 diabetes mellitus. Lancet. 2003, 361, 226–228.
  • Kondo H, Shimomura I, Matsukawa Y, Kumada M, Takahashi M, Matsuda M, Ouchi N, Kihara S, Kawamoto T, Sumitsuji S, Funahashi T, Matsuzawa Y. Association of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndrome. Diabetes. 2002, 51, 2325–2328.
  • Wang Y, Xu A, Knight C, Xu LY, Cooper GJ. Hydroxylation and glycosylation of the four conserved lysine residues in the collagenous domain of adiponectin. Potential role in the modulation of its insulin-sensitizing activity. J Biol Chem. 2002, 277, 19521–19529.
  • Tsao TS, Lodish HF, Fruebis J. ACRP30, a new hormone controlling fat and glucose metabolism. Eur J Pharmacol. 2002, 440, 213–21.
  • Das K, Lin Y, Widen E, Zhang
Related Products Docs