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Alpha-1 Acidic-Glycoprotein Rat ELISA

  • Regulatory status:RUO
  • Type:Sandwich ELISA, HRP-labelled antibody
  • Other names:AGP1, Orosomucoid-1, OMD1, ORM1
  • Species:Rat
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Cat. No. Size Price


RSCPRE061R 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Sandwich ELISA, HRP-labelled antibody

Applications

Serum, Plasma-EDTA, Plasma-Heparin, Urine

Sample Requirements

20 µl/well

Storage/Expiration

Stability is assured until the demonstrated expiration date (one year after manufacture), following storage in the dark and cool place (2–10°C).

Calibration Curve

Calibration Range

1.25–40 ng/ml

Intra-assay (Within-Run)

n = 8; CV = 3.9%

Inter-assay (Run-to-Run)

n = 8; CV = 6.8%

Spiking Recovery

102,90%

Summary

Research topic

Animal studies, Immune Response, Infection and Inflammation, Oncology

Summary

Alpha-1-acid glycoprotein (α1-AG) is an acute phase protein, which is nonspecifically increased in the plasma during acute inflammation. Thus, it becomes the indication for acute and chronic inflammatory diseases and tissue injury.

References to Summary

References to Alpha-1-Acidic Glycoprotein

  • Christiansen MS, Hesse D, Ekbom P, Hesse U, Damm P, Hommel E, Feldt-Rasmussen B, Mathiesen E. Increased urinary orosomucoid excretion predicts preeclampsia in pregnant women with pregestational type 1 diabetes. Diabetes Res Clin Pract. 2010 Jul;89 (1):16-21
  • Christiansen MS, Hommel E, Magid E, Feldt-Rasmussen B. Orosomucoid in urine predicts cardiovascular and over-all mortality in patients with Type II diabetes. Diabetologia. 2002 Jan;45 (1):115-20
  • Harley J, Roberts R, Joyce P, Mulder R, Luty S, Frampton C, Kennedy M. Orosomucoid influences the response to antidepressants in major depressive disorder. J Psychopharmacol. 2010 Apr;24 (4):531-5
  • Ligresti G, Aplin AC, Dunn BE, Morishita A, Nicosia RF. The acute phase reactant orosomucoid-1 is a bimodal regulator of angiogenesis with time- and context-dependent inhibitory and stimulatory properties. PLoS One. 2012;7 (8):e41387
  • Sochacka J, Pawelczak B. Characterization of 6-mercaptopurine binding site on human alpha1-acid glycoprotein (orosomucoid) using molecular docking. Acta Pol Pharm. 2012 Jan-Feb;69 (1):161-6
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