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Alpha CrossLaps® ELISA (αCTX-I)

  • Regulatory status:RUO
  • Type:Sandwich ELISA, HRP-labelled antibody
  • Other names:C-terminal telopeptide I, carboxy-terminal collagen I crosslinks
  • Species:Human
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Cat. No. Size Price


AC-04F1 96 wells
PubMed Product Details
Technical Data

Type

Sandwich ELISA, HRP-labelled antibody

Description

The ALPHA CrossLaps® (CTX-I) ELISA is an enzyme-linked immunosorbent assay for the quantification of non-isomerized fragments of C-terminal telopeptides of Type-I collagen (α CTX-I) in human urine. The ALPHA CrossLaps® (CTX-I) ELISA is intended for use as an indicator of degradation of non-isomerised bone collagen and may be used as an aid in the identification of skeletal metastases in patients with breast and prostate cancer. In addition, the ALPHA CrossLaps®(CTX-I) ELISA may be applied to humans as an aid in the diagnosis of Paget’s disease and the monitoring of anti-resorptive therapy in patients with Paget’s disease.

Scientific Description:

Type I collagen accounts for more than 90% of the organic matrix of bone and is synthesised primarily in bone. During renewal of the skeleton, type I collagen is degraded, and small peptide fragments are excreted into the urine. These fragments can be measured by the ALPHA CrossLaps® (CTX-I) ELISA. The ALPHA CrossLaps® (CTX-I) ELISA is based on one highly specific monoclonal antibody against the amino acid sequence of EKAHDGGR. In order to obtain a specific signal in the ALPHA CrossLaps® (CTX-I) ELISA, two chains of EKAHDGGR must be cross linked.

Applications

Urine

Sample Requirements

45 µL (excluding dead volume) 25 μL pre-diluted (1+7)

Storage/Expiration

Store the complete kit at 2-8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Range

0-1600 ng/mL

Limit of Detection

0.80 ng/mL ALPHA CrossLaps

Summary

Features

  • Supports clinical assessment in pathological high bone turnover
  • FDA IVD assay supporting bone disease management

Research topic

Bone and cartilage metabolism

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