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Manufactured by BioVendor

Betatrophin Human ELISA

  • Regulatory status:RUO
  • Type:Sandwich ELISA, Biotin-labelled antibody
  • Other names:RIFL, Hepatocellular carcinoma-associated protein TD26, C19orf80, UNQ599/PRO1185, Lipasin, Angiopoietin-like protein 8, ANGPTL-8, ANGPTL 8, ANGPTL8
  • Species:Human
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Cat. No. Size Price


RD191347200R 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Sandwich ELISA, Biotin-labelled antibody

Applications

Serum, Plasma-EDTA, Plasma-Heparin, Plasma-Citrate

Sample Requirements

20 µl/well

Shipping

At ambient temperature. Upon receipt, store the product at the temperature recommended below.

Storage/Expiration

Store the kit at 2–8°C. Under these conditions, assay components are stable till the expiry date is over. (See the expiry date indicated on the kit label).

Calibration Curve

Calibration Range

0.31 – 20 ng/ml

Limit of Detection

0.244 ng/ml

Intra-assay (Within-Run)

n = 8; CV = 7.4 %

Inter-assay (Run-to-Run)

n = 6; CV = 3.9 %

Spiking Recovery

99.3 %

Dilution Linearity

95.9 %

Summary

Features

  • It is intended for research use only
  • The total assay time is less than 4 hours
  • The kit measures betatrophin in serum and plasma (EDTA, citrate and heparine)
  • Assay format is 96 wells
  • Standard is native protein based
  • Components of the kit are provided ready to use, concentrated or lyophilized

Research topic

Diabetology - Other Relevant Products, Energy metabolism and body weight regulation, Lipoprotein metabolism

Summary

Lipasin (RIFL) is an important new regulator of lipid metabolism that regulates serum triglyceride levels. It is a member of ANGPTL protein family.

Product References (2)

References

  • Leiherer A, Ebner J, Muendlein A, Brandtner EM, Zach C, Geiger K, Fraunberger P, Drexel H. Data on the power of high betatrophin to predict cardiovasculardeaths in coronary patients. Data Brief. 2019 Dec 12;28:104989. doi:10.1016/j.dib.2019.104989. eCollection 2020 Feb. PubMed PMID: 31890821; PubMedCentral PMCID: PMC6931085. See more on PubMed
  • Leiherer A, Ebner J, Muendlein A, Brandtner EM, Zach C, Geiger K, Fraunberger P, Drexel H. High betatrophin in coronary patients protects from cardiovascularevents. Atherosclerosis. 2019 Nov 15;293:62-68. doi:10.1016/j.atherosclerosis.2019.11.011. [Epub ahead of print] PubMed PMID:31862484. See more on PubMed
Summary References (9)

References to Betatrophin

  • Espes D, Lau J, Carlsson PO. Increased circulating levels of betatrophin in individuals with long-standing type 1 diabetes. Diabetologia. 2014 Jan;57 (1):50-3
  • Espes D, ORCID: 0000-0001-8843-7941, Martinell M, ORCID: 0000-0002-6060-6229, Carlsson PO, ORCID: 0000-0002-7666-073X. Increased circulating betatrophin concentrations in patients with type 2 diabetes. Int J Endocrinol. 2014;2014:323407
  • Jiao Y, Le Lay J, Yu M, Naji A, Kaestner KH. Elevated mouse hepatic betatrophin expression does not increase human beta-cell replication in the transplant setting. Diabetes. 2014 Apr;63 (4):1283-8
  • Raghow R. Betatrophin: A liver-derived hormone for the pancreatic beta-cell proliferation. World J Diabetes. 2013 Dec 15;4 (6):234-7
  • Salas E, Rabhi N, Froguel P, Annicotte JS. Role of Ink4a/Arf locus in beta cell mass expansion under physiological and pathological conditions. J Diabetes Res. 2014;2014:873679
  • Trebotic LK, Klimek P, Thomas A, Fenzl A, Leitner K, Springer S, Kiefer FW, Kautzky-Willer A. Circulating Betatrophin Is Strongly Increased in Pregnancy and Gestational Diabetes Mellitus. PLoS One. 2015;10 (9):e0136701
  • Wang Y, Quagliarini F, Gusarova V, Gromada J, Valenzuela DM, Cohen JC, Hobbs HH. Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis. Proc Natl Acad Sci U S A. 2013 Oct 1;110 (40):16109-14
  • Yi P, Park JS, Melton DA. Betatrophin: a hormone that controls pancreatic beta cell proliferation. Cell. 2013 May 9;153 (4):747-58
  • Zhang R, Abou-Samra AB. A dual role of lipasin (betatrophin) in lipid metabolism and glucose homeostasis: consensus and controversy. Cardiovasc Diabetol. 2014;13:133
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