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Manufactured by BioVendor

Betatrophin Human ELISA

  • Regulatory status:RUO
  • Type:Sandwich ELISA, Biotin-labelled antibody
  • Other names:RIFL, Hepatocellular carcinoma-associated protein TD26, C19orf80, UNQ599/PRO1185, Lipasin, Angiopoietin-like protein 8
  • Species:Human
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New RD191347200R 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Sandwich ELISA, Biotin-labelled antibody

Applications

Serum, Plasma-EDTA, Plasma-Heparin, Plasma-Citrate

Sample Requirements

20 µl/well

Storage/Expiration

Store the kit at 2–8°C. Under these conditions, assay components are stable till the expiry date is over. (See the expiry date indicated on the kit label).

Calibration Curve

Calibration Range

0.31 – 20 ng/ml

Limit of Detection

0.244 ng/ml

Intra-assay (Within-Run)

n = 8; CV = 7.4 %

Inter-assay (Run-to-Run)

n = 6; CV = 3.9 %

Spiking Recovery

99.3 %

Dilutation Linearity

95.9 %

Summary

Features

  • It is intended for research use only
  • The total assay time is less than 4 hours
  • The kit measures betatrophin in serum and plasma (EDTA, citrate and heparine)
  • Assay format is 96 wells
  • Standard is native protein based
  • Components of the kit are provided ready to use, concentrated or lyophilized

Research topic

Diabetology - Other Relevant Products, Energy metabolism and body weight regulation, Lipoprotein metabolism

Summary

Lipasin (RIFL) is an important new regulator of lipid metabolism that regulates serum triglyceride levels. It is a member of ANGPTL protein family.

References to Summary

References to Betatrophin

  • Espes D, Lau J, Carlsson PO. Increased circulating levels of betatrophin in individuals with long-standing type 1 diabetes. Diabetologia. 2014 Jan;57 (1):50-3
  • Espes D, ORCID: 0000-0001-8843-7941, Martinell M, ORCID: 0000-0002-6060-6229, Carlsson PO, ORCID: 0000-0002-7666-073X. Increased circulating betatrophin concentrations in patients with type 2 diabetes. Int J Endocrinol. 2014;2014:323407
  • Jiao Y, Le Lay J, Yu M, Naji A, Kaestner KH. Elevated mouse hepatic betatrophin expression does not increase human beta-cell replication in the transplant setting. Diabetes. 2014 Apr;63 (4):1283-8
  • Raghow R. Betatrophin: A liver-derived hormone for the pancreatic beta-cell proliferation. World J Diabetes. 2013 Dec 15;4 (6):234-7
  • Salas E, Rabhi N, Froguel P, Annicotte JS. Role of Ink4a/Arf locus in beta cell mass expansion under physiological and pathological conditions. J Diabetes Res. 2014;2014:873679
  • Trebotic LK, Klimek P, Thomas A, Fenzl A, Leitner K, Springer S, Kiefer FW, Kautzky-Willer A. Circulating Betatrophin Is Strongly Increased in Pregnancy and Gestational Diabetes Mellitus. PLoS One. 2015;10 (9):e0136701
  • Wang Y, Quagliarini F, Gusarova V, Gromada J, Valenzuela DM, Cohen JC, Hobbs HH. Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis. Proc Natl Acad Sci U S A. 2013 Oct 1;110 (40):16109-14
  • Yi P, Park JS, Melton DA. Betatrophin: a hormone that controls pancreatic beta cell proliferation. Cell. 2013 May 9;153 (4):747-58
  • Zhang R, Abou-Samra AB. A dual role of lipasin (betatrophin) in lipid metabolism and glucose homeostasis: consensus and controversy. Cardiovasc Diabetol. 2014;13:133
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