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Manufactured by BioVendor

CCL2 (MCP-1) Human E. coli

  • Regulatory status:RUO
  • Type:Recombinant protein
  • Source:E. coli
  • Other names:MCP-1, C-C motif chemokine 2, CCl2, MCP1, SCYA2
  • Species:Human
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Cat. No. Size Price

RD172386050 0.05 mg
PubMed Product Details
Technical Data


Recombinant protein


Total 76 AA. MW: 8,7 kDa (calculated). UniProtKB–99) Protein identity confirmed by LC-MS/MS.

Amino Acid Sequence



E. coli


Purity as determined by SDS PAGE: > 97%

Biological Activity

EC50 = 0.067nM determined by Migration of recombinant CCR2 containing cells


<0.01 EU /1µg


Add sterile water to prepare a working stock solution of approximately 0.1 mg/ml and let the lyophilized pellet dissolve completely.


Western blotting, ELISA, Cell culture and/or animal studies, Biologically active protein


At ambient temperature. Upon receipt, store the product at the temperature recommended below.


Store the lyophilized protein at –20 to –70 °C. Lyophilized protein remains stable until the expiry date when stored at-20 to –70 °C. Aliquot reconstituted protein to avoid repeated freezing/thawing cycles and store at -20 to –70 °C, the protein is stable for 3 months at –20 to –70 °C under sterile conditions after reconstitution. Reconstituted protein can be stored at 4 °C for 1 month under sterile conditions after reconstitution

Quality Control Test

Quantification is done by A280, using the calculated extinction coefficient (10486 M-1 cm-1).
SDS-PAGE to determine purity of the protein.
LAL TEST to determine endotoxin level.


This product is intended for research use only.


Research topic

Chemokines, Cytokines and chemokines and related molecules, Energy metabolism and body weight regulation


Monocyte chemoattractant protein-1 (MCP-1) (CCL2) is produced by many cell types at sites of inflammation. It regulates chemotaxis and transendothielial migration of monocytes, as well as memory T cells and natural killer cells by interacting with their membrane surface receptor CCR2. MCP-1 has also been implicated in a number of disease states, such as rheumatoid arthritis, atherosclerosis, autoimmune diseases, tumor progression, and HIV infection.

Product References (1)


  • Cimmino F, Catapano A, Trinchese G, Cavaliere G, Culurciello R, Fogliano C, Penna E, Lucci V, Crispino M, Avallone B, Pizzo E, Mollica MP. Dietary Micronutrient Management to Treat Mitochondrial Dysfunction in Diet-Induced Obese Mice. Int J Mol Sci. 2021 Mar 11;22(6):2862. doi: 10.3390/ijms22062862. PMID: 33799812; PMCID: PMC8000238. See more on PubMed
Summary References (3)

References to CCL2

  • Deshmane SL, Kremlev S, Amini S, Sawaya BE. Monocyte chemoattractant protein-1 (MCP-1): an overview. J Interferon Cytokine Res. 2009 Jun;29 (6):313-26
  • Melgarejo E, Medina MA, Sanchez-Jimenez F, Urdiales JL. Monocyte chemoattractant protein-1: a key mediator in inflammatory processes. Int J Biochem Cell Biol. 2009 May;41 (5):998-1001
  • Yoshimura T, Yuhki N, Moore SK, Appella E, Lerman MI, Leonard EJ. Human monocyte chemoattractant protein-1 (MCP-1). Full-length cDNA cloning, expression in mitogen-stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE. FEBS Lett. 1989 Feb 27;244 (2):487-93
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