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Manufactured by BioVendor

CCL3 (MIP-1α) Human E. coli

  • Regulatory status:RUO
  • Type:Recombinant protein
  • Source:E. coli
  • Other names:MIP-1α, C-C motif chemokine 3, G0/G1 switch regulatory protein 19-1 Macrophage inflammatory protein 1-alpha, PAT 464.1, SIS-beta, Small-inducible cytokine A3, Tonsillar lymphocyte LD78 alpha protein, G0S19-1, MIP1A, SCYA3, CCL3
  • Species:Human
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Cat. No. Size Price

RD172389050 0.05 mg
PubMed Product Details
Technical Data


Recombinant protein


Total 69 AA. MW: 7,7 kDa (calculated). UniProtKB P10147 (24–92) Protein identity confirmed by LC-MS/MS.

Amino Acid Sequence



E. coli


> 97% by SDS PAGE

Biological Activity

EC50 = 0.1–0.3nM determined by Migration Assay in cells expressing recombinant CCR5


<0.01 EU/1µg


Add sterile water to prepare a working stock solution of approximately 0.1 mg/ml and let the lyophilized pellet dissolve completely.


Western blotting, ELISA, Cell culture and/or animal studies, Biologically active protein


At ambient temperature. Upon receipt, store the product at the temperature recommended below.


Store the lyophilized protein at –20 to –70 °C. Lyophilized protein remains stable until the expiry date when stored at-20 to –70 °C. Aliquot reconstituted protein to avoid repeated freezing/thawing cycles and store at -20 to –70 °C, the protein is stable for 3 months at –20 to –70 °C under sterile conditions after reconstitution. Reconstituted protein can be stored at 4 °C for 1 month under sterile conditions after reconstitution

Quality Control Test

Quantification is done by A280, using the calculated extinction coefficient (10010 M-1 cm-1).
SDS-PAGE to determine purity of the protein.
LAL TEST to determine endotoxin level.


This product is intended for research use only.


Research topic

Chemokines, Cytokines and chemokines and related molecules


Macrophage inflammatory proteins 1-α (MIP1α)(CCL3) binds to cell surface receptors CCR1 and CCR5. It is proinflammatory, leading to chemotaxis and activation of immune cells. It also inhibits proliferation of hematopoietic stem cells. Moreover, by binding to one of the HIV coreceptors, CCR5, it suppresses HIV infection.

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